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Method of screening an antibody for activity in clearing an amyloid deposit

  • US 7,575,880 B1
  • Filed: 11/28/2000
  • Issued: 08/18/2009
  • Est. Priority Date: 05/26/2000
  • Status: Expired due to Fees
First Claim
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1. A method of screening a monoclonal antibody for activity in inducing clearance of an amyloid deposit of Aβ

  • , comprising;

    combining the amyloid deposit, a monoclonal antibody which binds to an epitope within amino acid residues 1-7 of Aβ

    , and microglial cells bearing Fc receptors in a medium in vitro; and

    by a series of measurements, monitoring whether a reduction in the amount of the amyloid deposit remaining in the medium occurs, as compared to a baseline measurement, a reduction in the amount of the amyloid deposit indicating the monoclonal antibody induces phagocytic clearing activity of the microglial cells against the amyloid deposit.

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