Modification of selectivity for sensing for nanostructure device arrays

• US 7,575,933 B2
• Filed: 05/27/2005
• Issued: 08/18/2009
• Est. Priority Date: 03/15/2002
• Status: Expired due to Fees

• Current Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Original Assignee: Nanomix Incorporated (CJY Holdings Ltd.)
• Inventors: Bradley, Keith, Gruner, George, Gabriel, Jean-Christophe P., Collins, Philip G.
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US11/139,184
• Publication Number:
  US 20060078468A1
• Time in Patent Office: 1,544 Days
• Field of Search: 295/92, 295/921, 422/50, 422/55, 422/56, 422/57, 422/58, 422/68.1, 422/69, 422/82.01, 422/82.02, 422/83, 422/90.98, 422/90, 422/98, 436/43, 436/63, 436/64, 436/65, 436/66, 436/68, 436/71, 436/73, 436/74, 436/75, 436/149, 436/150, 436/151, 204/193, 204/194, 204/400, 204/403.01, 204/403.03, 204/403.13, 204/406, 204/407, 73/10.1, 73/10.2, 73/190.1, 73/232, 73/530.1, 438 48- 49, 977/700, 977/840, 977/855, 977/882, 977/902, 977/920, 977/953, 977/957, 977/958
• US Class Current: 436/151
• CPC Class Codes: B01J 2219/00653 the compounds being bound to electrodes embedded in or on the solid supports
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 27/126 comprising organic polymers
• CPC Class Codes: G01N 27/127 comprising nanoparticles
• CPC Class Codes: Y10S 977/84 Manufacture, treatment, or detection of nanostructure
• CPC Class Codes: Y10S 977/855 for manufacture of nanostructure
• CPC Class Codes: Y10S 977/882 Assembling of separate components, e.g. by attaching
• CPC Class Codes: Y10S 977/92 Detection of biochemical
• CPC Class Codes: Y10S 977/957 Of chemical property or presence
• CPC Class Codes: Y10S 977/958 Of biomolecule property
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided. The methods involve comparing signals from nanostructure sensing devices that have not been exposed to the chemical species of interest with signals from nanostructure sensing devices that have been exposed to the chemical species of interest. Nanostructure sensing device array structures that can measure and subtract out environmental factors are also disclosed.

Claims

1. A method of fabricating a sensor for detecting a plurality of analytes, the method comprising:

(a) forming a plurality of nanostructure sensing devices on a substrate, wherein each nanostructure sensing device comprises;

(i) a nanostructure,

(ii) at least two contact electrodes in electrical communication via the nanostructure, and

(iii) at least one structure selected from the group consisting of a protective coating disposed over the contact electrodes and a gate electrode in electrical communication with the nanostructure;

(b) adapting individual nanostructure sensing devices for sensitivity to different analytes of the plurality of analytes, wherein adapting individual nanostructure sensing devices comprises exposing at least some of the plurality of nanostructure sensing devices to a reactant, wherein the reactant is selected from the group consisting of a gas and an electrochemical solution; and

(c) forming signal connections to the individual nanostructure sensing devices, the signal connections adapted to transmit signals indicating responses of corresponding nanostructure sensing devices to the plurality of analytes.

2. The method of claim 1, further comprising connecting the plurality of nano structure sensing devices to a processing system via electrical connections, wherein the processing system comprises a processor configured to analyze signals from the plurality of nanostructure sensing devices to provide identification of the different analytes.

3. The method of claim 1, wherein the signal connections are adapted to transmit signals selected from the group consisting of electrical signals, optical signals, mechanical signals and thermal signals.

4. The method of claim 1, wherein the adapting the individual nanostructure sensing devices further comprises supplying energy to the reactant, wherein the energy is selected from the group consisting of ultraviolet radiation, thermal energy, and electrical energy.

5. The method of claim 1, wherein the adapting the individual nanostructure sensing devices further comprises adapting the plurality of nanostructure sensing devices for sensitivity to same members of the plurality of analytes, and then selectively shielding ones of the nanostructure sensing devices from different members of the plurality of analytes.

6. The method of claim 1, wherein the adapting the individual nanostructure sensing devices further comprises adapting the plurality of nanostructure sensing devices for sensitivity to same members of the plurality of analytes, and then selectively shielding at least one of the nanostructure sensing devices from each of the plurality of analytes.

7. The method of claim 1, wherein the adapting the individual nano structure sensing devices further comprises adapting the plurality of nanostructure sensing devices for sensitivity to same members of the plurality of analytes in water, and then selectively shielding at least one of the nano structure sensing devices from water.

8. The method of claim 1, wherein the forming the signal connections further comprises arranging the plurality of nanostructure sensing devices in an array.

9. The method of claim 1, wherein the nanostructure comprises a network of nanostructures, the network including a plurality of nanostructures which are oriented to contact one another, the network configured to electrically communicate with the electrodes.

10. The method of claim 9, wherein the network of nanostructures of at least one nanostructure sensing devices includes a plurality of carbon nanotubes.

11. The method of claim 9, wherein the network of nanostructures of at least one nanostructure sensing devices is covered by a selectively-permeable coating.

12. The method of claim 9, wherein the network of nanostructures of at least one nanostructure sensing devices is covered by an impermeable coating.