Long term analyte sensor array
First Claim
1. An analyte sensing device for sensing at least one analyte, the analyte sensing device comprising:
- an array of sealable wells;
wherein each sealable well comprises an analyte sensor having a plurality of analyte sensor elements adapted to contact and sense analyte, the analyte sensor elements comprising;
a base layer;
at least three working electrodes disposed on the base layer;
a glucose oxidase layer disposed upon the at least three working electrodes, wherein the least three working electrodes are coated with the glucose oxidase layer so as to allow the analyte sensing device to sense glucose;
an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition that includes a compound selected for its ability to crosslink to a siloxane composition;
an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a siloxane composition crosslinked to the compound in the analyte modulating layer and;
at least one analyte sensor membrane disposed upon at least one sealable well in a manner that reversibly prevents an analyte from contacting the at least one of the plurality of analyte sensors, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and
at least one structure operatively coupled to the analyte sensing device for relaying information away from the analyte sensing device.
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Accused Products
Abstract
A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
60 Citations
20 Claims
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1. An analyte sensing device for sensing at least one analyte, the analyte sensing device comprising:
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an array of sealable wells;
wherein each sealable well comprises an analyte sensor having a plurality of analyte sensor elements adapted to contact and sense analyte, the analyte sensor elements comprising;a base layer; at least three working electrodes disposed on the base layer; a glucose oxidase layer disposed upon the at least three working electrodes, wherein the least three working electrodes are coated with the glucose oxidase layer so as to allow the analyte sensing device to sense glucose; an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition that includes a compound selected for its ability to crosslink to a siloxane composition; an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a siloxane composition crosslinked to the compound in the analyte modulating layer and; at least one analyte sensor membrane disposed upon at least one sealable well in a manner that reversibly prevents an analyte from contacting the at least one of the plurality of analyte sensors, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and at least one structure operatively coupled to the analyte sensing device for relaying information away from the analyte sensing device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification