Device and method for measuring the elasticity of a human or animal organ

• US 7,578,789 B2
• Filed: 02/02/2005
• Issued: 08/25/2009
• Est. Priority Date: 08/08/2002
• Status: Active Grant

• Current Assignee: Echosens SA (Inner Mongolia Furui Medical Science Co., Ltd.)
• Original Assignee: Echosens Co.
• Inventors: Sandrin, Laurent, Hasquenoph, Jean-Michel
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Selkin; Saurel J
• Application Number:
  US11/049,400
• Publication Number:
  US 20050203398A1
• Time in Patent Office: 1,665 Days
• Field of Search: 600437-461, 604/19, 604/20, 604/601, 604/606, 735/97, 735/73
• US Class Current: 600/438
• CPC Class Codes: A61B 5/0048 Detecting, measuring or recording by applying mechanical forces or stimuli A61B5/021, A61B5/4884 and A61B9/00 take precedence
• CPC Class Codes: A61B 5/0051 by applying vibrations
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/4245 involving determining the position of the probe, e.g. with respect to an external reference frame or to the patient
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties

Abstract

A device for measuring elasticity of a human or animal organ or viscoelastic media having an ultrasonic signal after ultrasonic illumination including at least one sensor including an ultrasonic transducer, at least one position sensor, an actuator to trigger the device connected by wire link to an electric power source, and a controlled electrodynamic actuator attached to the ultrasonic transducer that generates a transitory low-frequency impulse having a frequency range between about 1 Hz and about 5000 Hz.

Claims

1. A device for measuring elasticity of a human or animal organ or viscoelastic media having an ultrasonic signal after being subjected to ultrasonic impulses comprising:

at least one sensor comprising an ultrasonic transducer,

at least one position sensor,

an actuator to trigger the device connected by wire link to an electric power source,

a controlled electrodynamic actuator attached to the ultrasonic transducer that generates a transitory low-frequency impulse having a frequency range between about 1 Hz and about 5000 Hz and results in a low-frequency vibration or stress that is controlled in time and amplitude and allows an operator to apply pressure to the organ, and

a computer configured to calculate velocities of tissue deformations.

2. The device according to claim 1, further comprising at least one controller connected to the sensor.

3. The device according to claim 2, wherein the controller is selected from the group consisting of a computer, a microcomputer and a central processing unit.

4. The device according to claim 1, wherein the sensor comprises a flexible, watertight membrane.

5. The device according to claim 1, wherein the sensor comprises a protective device that protects the ultrasonic transducer.

6. The device according to claim 1, wherein the sensor connects to a control module and an ultrasound acquisition module that communicate with each other.

7. The device according to claim 2, wherein the controller communicates with the control module and the ultrasound acquisition module.

8. The device according to claim 2, further comprising a user interface connected to the controller.

9. The device according to claim 1, wherein the sensor connects to at least one echograph that displays obtained images on a screen.

10. The device according to claim 9, wherein the electrograph further comprises an echographic bar and the bar implements acquisition of ultrasound signals.

11. The device according to claim 1, further comprising at least three receivers for arrangement on a body of a patient and at least one transmitter placed on the sensor.

14. The device according to claim 8, wherein the controller and the user interface are electrically powered by at least one battery.

15. The device according to claim 1, further comprising a device for calculating displacements connected to the sensor which is adapted as a function of the depth of the human or animal organ.

16. The device according to claim 1, wherein at least an end of ultrasonic transducer has an elongated shape, and has a length between about 2 and about 20 millimeters, and a width between about 1 and about 10 millimeters.

17. The device according to claim 1, wherein the ultrasonic transducer has a conical or tapered form having an angle between about 10 and about 80 degrees.

27. The device according to claim 6, wherein a controller communicates with the control module and the ultrasound acquisition module.

12. A device for measuring elasticity of a human or animal organ or viscoelastic media having an ultrasonic signal after being subjected to ultrasonic impulses comprising:

at least one sensor comprising an ultrasonic transducer,

at least one position sensor,

an actuator to trigger the device connected by wire link to an electric power source, and

a controlled electrodynamic actuator attached to the ultrasonic transducer that generates a transitory low-frequency impulse having a frequency range between about 1 Hz and about 5000 Hz, and further comprising an elastic intermediary medium adjacent to the transducer and transparent to ultrasound and the low-frequency impulse.

13. The device according to claim 12, wherein the intermediary medium has an elasticity close to that of a medium being measured by compressing the intermediary medium in a manner to vary its modulus of elasticity.

18. A method for determining elasticity of a human or animal organ or viscoelastic media having an ultrasonic signal after being subjected to ultrasonic impulses with a device comprising at least one ultrasonic transducer, at least one position sensor, a controlled electrodynamic actuator connected by wire link to an electric power source, comprising:

generating a low-frequency impulse with the ultrasonic transducer and acquiring ultrasonic signals with the ultrasonic transducer,

compensating for relative displacement of the transducer,

determining tissue velocities by using displacements between acquired signals in the organ/media,

determining velocities of tissue deformations,

determining velocity of the elastic wave, and

determining the elasticity according to E=3pV_s², wherein E is elasticity, p is density of the organ and V_s is velocity of the elastic wave.

19. The method according to claim 18, further comprising a prior step of localization by image mode of a desired zone, and wherein acquisition of the ultrasound signals takes place at a selected cadence of about 50 lines per second.

20. The method according to claim 19, wherein results obtained from determining the elasticity is superposed on the ultrasound signals in the form of a level of different color.

21. The method according to claim 18, wherein the low-frequency impulse has a frequency between about 1 Hz and about 5000 Hz and a duration ranging from about 1/2f to about 20/f.

22. The method according to claim 18, wherein determining the tissue velocity is implemented by intercorrelation, by Doppler, by autocorrelation or a technique for measurement of displacements.

23. The method according to claim 18, wherein determining the velocity of tissue deformation is performed by deriving the tissue velocity by depth.

24. The method according to claim 18, wherein the acquisition of signals is performed at a cadence between about 100 Hz and about 100,000 Hz.

25. The method according to claim 18, further comprising a prior step of scanning the human or animal organ manually or using a step motor or controlled electromagnetic actuators.

26. The method according to claim 18, further comprising a step of automatic recognition of the medium by calculating the coefficient of ultrasonic retrodiffusion.