Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions

• US 7,578,996 B2
• Filed: 04/07/2004
• Issued: 08/25/2009
• Est. Priority Date: 04/07/2004
• Status: Active Grant

• Current Assignee: Johnson & Johnson Surgical Vision, Inc. (Johnson & Johnson)
• Original Assignee: Advanced Medical Optics Incorporated (Johnson & Johnson)
• Inventors: Huth, Stanley W., Yu, Zhi-Jian
• Primary Examiner(s): Richter; Johann R
• Assistant Examiner(s): BROWN, COURTNEY A
• Application Number:
  US10/820,486
• Publication Number:
  US 20050226841A1
• Time in Patent Office: 1,966 Days
• Field of Search: 424/405, 424/70.31, 510/112
• US Class Current: 424/70.31
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A61L 12/14 Organic compounds not covered by groups A61L12/10 or A61L12/12
• CPC Class Codes: A61L 12/143 Quaternary ammonium compounds
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C11D 1/008 Polymeric surface-active agents
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/222 Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
• CPC Class Codes: C11D 3/28 Heterocyclic compounds containing nitrogen in the ring
• CPC Class Codes: C11D 3/3409 Alkyl -, alkenyl -, cycloalkyl - or terpene sulfates or sulfonates
• CPC Class Codes: C11D 3/349 additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

A multi-purpose contact lens care solution having high antimicrobial activity comprising, in an aqueous liquid medium, cetylpyridinium chloride and a non-ionic surfactant. In one embodiment of the invention, the non-ionic surfactant is a poly(oxypropylene)-poly(oxyethylene) block copolymer. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and/or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.

Claims

1. A multi-purpose solution comprising:

an aqueous liquid medium;

about 0.1 ppm to about 9.5 ppm cetylpyridinium chloride; and

a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution.

2. The solution as in claim 1, wherein the solution comprises about 0.5 ppm to about 9 ppm cetylpyridinium chloride.

3. The solution as in claim 1, further comprising a second antimicrobial component.

4. The solution as in claim 1, further comprising a viscosity inducing component selected from the group consisting of cellulosic derivatives and mixtures thereof in the range of about 0.05% to about 5.0% (w/v) of the total solution.

5. The solution as in claim 1, further comprising a buffer component in an amount effective in maintaining the pH of said solution within a physiologically acceptable range.

6. The solution as in claim 1, wherein the buffer is selected from the group consisting of boric acid/sodium hydroxide buffers and boric acid/sodium borate buffers.

7. A multi-purpose solution for contact lens care comprising:

an aqueous liquid medium;

about 0.1 ppm to about 9.5 ppm cetylpyridinium chloride;

a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution;

a buffer component in an amount effective in maintaining the pH of said solution within a physiologically acceptable range;

a viscosity inducing component selected from the group consisting of cellulosic derivatives and mixtures thereof;

a chelating component; and

a tonicity component in an amount effective in providing the desired tonicity to said solution.

8. The multi-purpose solution of claim 7, further comprising a second antimicrobial component.

9. The multi-purpose solution of claim 7, wherein the second antimicrobial component is present in an amount ranging from about 0.1 ppm to about 3 ppm.

10. The multi-purpose solution of claim 7, wherein the poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant is present in an amount in a range of about 0.01% to about 1.0% (w/v).

11. The multi-purpose solution of claim 7, wherein the buffer component includes boric acid.

12. The multi-purpose solution of claim 7, further comprising taurine.

13. A multi-purpose solution comprising:

an aqueous liquid medium;

about 0.1 to about 9.5 ppm of cetylpyridinium chloride;

a second antimicrobial agent;

a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution; and

taurine in an amount effective to protect ocular tissue cell membranes.