Methods for enhancing antioxidant enzyme activity and reducing c-reactive protein levels

• US 7,579,026 B2
• Filed: 08/31/2005
• Issued: 08/25/2009
• Est. Priority Date: 03/23/2004
• Status: Active Grant

• Current Assignee: Lifeline Nutraceuticals Corporation
• Original Assignee: Lifeline Nutraceuticals Corporation
• Inventors: Driscoll, William J., Myhill, Paul R.
• Primary Examiner(s): HOFFMAN, SUSAN COE
• Application Number:
  US11/216,514
• Publication Number:
  US 20060008544A1
• Time in Patent Office: 1,455 Days
• Field of Search: None
• US Class Current: 424/729
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/16 Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• CPC Class Codes: A61K 36/23 Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/63 Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
• CPC Class Codes: A61K 36/68 Plantaginaceae (Plantain Family)
• CPC Class Codes: A61K 36/80 Scrophulariaceae (Figwort family)
• CPC Class Codes: A61K 36/81 Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/886 Aloeaceae (Aloe family), e.g. aloe vera
• CPC Class Codes: A61K 36/9066 Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 38/446 Superoxide dismutase (1.15)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/18 : for HIV
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 39/00 : General protective or antinoxious agents
• CPC Class Codes: A61P 39/06 : Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/06 : Antianaemics
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 : Antihypertensives

Abstract

An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed comprising Bacopa monniera extract; milk thistle extract, ashwagandha powder, green tea extract, Gotu kola powder, Ginko biloba leaf extract; Aloe vera powder; turmeric extract; and N-acetyl cysteine. The antioxidant-promoting composition of the invention safely induces cellular antioxidant potential to achieve an overall net decrease in oxidative stress without the undesirable side-effects associated with the individual components of the antioxidant-promoting composition. Also disclosed is a method for reducing the undesirable side-effects of free radicals in a subject by administering to a subject in need of such antioxidants an effective amount of antioxidant-promoting composition of the invention.

Claims

1. A method of increasing antioxidant enzyme activity in a subject, said method comprising administering to a subject in need thereof an effective amount of a composition comprising:

at least 150 milligrams Bacopa monniera extract having 45 percent bacosides or greater;

at least 225 milligrams Silybum marianum (milk thistle) extract having between 70 percent and 80 percent silymarin;

at least 150 mg Withania somnifera (ashwagandha) powder;

at least 75 milligrams Camellia sinensis (green tea) extract having 98 percent polyphenols and 45 percent epigallocatechin gallate; and

at least 75 milligrams turmeric extract having 95 percent curcumin, wherein the composition reduces plaque formation in the vasculature of the subject thereby reducing excessive atherosclerosis or hypertension.

2. The method of claim 1, wherein the subject is administered from 650 mg/day to 1000 mg/day of the composition.

3. The method according to claim 1, wherein the composition is administered daily as an oral dietary supplement.

4. The method of claim 2, wherein the composition includes one or more excipients including:

calcium carbonate;

croscarmellose sodium;

dicalcium phosphate;

magnesium stearate;

microcrystalline cellulose;

modified cellulose;

silica; and

stearic acid.

5. A method of increasing antioxidant enzyme activity in a subject, said method comprising administering to a subject in need thereof an effective amount of a composition comprising:

up to 500 milligrams Bacopa monniera extract having 45 percent bacosides or greater;

up to 500 milligrams Silybum marianum (milk thistle) extract having between 70 percent and 80 percent silymarin;

up to 500 mg Withania somnifera (ashwagandha) powder;

up to 500 milligrams Camellia sinensis (green tea) extract having 98 percent polyphenols and 45 percent epigallocatechin gallate; and

up to 500 milligrams turmeric extract having 95 percent curcumin, wherein the composition reduces plaque formation in the vasculature of the subject thereby reducing excessive atherosclerosis or hypertension.