Method and system for stimulating a dorsal root ganglion

• US 7,580,753 B2
• Filed: 09/07/2005
• Issued: 08/25/2009
• Est. Priority Date: 09/08/2004
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories), Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Spinal Modulation, Inc. (Abbott Laboratories), Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Imran, Mir A., Kim, Daniel H.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Dinga; Roland
• Application Number:
  US11/221,583
• Publication Number:
  US 20060052826A1
• Time in Patent Office: 1,448 Days
• Field of Search: 607/116, 607/46, 607/2, 607/117, 607/118, 607/43, 607/45, 128/898, 128/899
• US Class Current: 607/46
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/06 Body-piercing guide needles or the like
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/0568 with drug delivery
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

Some embodiments of the present invention provide a pulse generator for high impedance electrodes as well as stimulation systems and components for selective stimulation and/or neuromodulation of targeted neural tissue. Targeted neural tissue may include one or more dorsal root ganglia with an electrode implanted on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

Claims

1. A method of stimulating a dorsal root ganglion comprising:

advancing an electrode substantially adjacent to a portion of a peripheral nerve toward the dorsal root ganglion and a midline of a spinal column without crossing the midline of the spinal column;

implanting the electrode in proximity to the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

2. A method as in claim 1, wherein advancing the electrode comprises advancing the electrode into a foramen.

3. A method as in claim 1, wherein implanting the electrode comprises positioning the electrode on the dorsal root ganglion.

4. A method as in claim 1, wherein implanting the electrode comprises inserting the electrode into the dorsal root ganglion.

5. A method as in claim 1, further comprising:

advancing another electrode adjacent to another peripheral nerve toward another dorsal root ganglion;

implanting the other electrode in proximity to the other dorsal root ganglion.

6. A method as in claim 5, wherein the dorsal root ganglion and the other dorsal root ganglion are on the same spinal level.

7. A method as in claim 5, wherein the dorsal root ganglion and the other dorsal root ganglion are on different spinal levels.

8. A method as in claim 1, wherein implanting comprises wrapping the electrode at least partially around the dorsal root ganglion.

9. A method as in claim 1, wherein advancing the electrode comprises advancing the electrode through a delivery device inserted outside of a spinal column.

10. A method of stimulating a dorsal root ganglion according to claim 1, the activating step further comprising:

activating the electrode to stimulate a portion of the dorsal root ganglion without activating a ventral root on the same spinal level as the dorsal root ganglion.

11. A method of stimulating a dorsal root ganglion of a patient comprising:

inserting a delivery device into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion;

advancing an electrode through the delivery device;

implanting the electrode on, in or about the dorsal root ganglion without entering an epidural space; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

12. A method as in claim 11, further comprising implanting a position sensor in the patient, wherein position sensor information is used to affect stimulation.

13. A method as in claim 11, wherein the position sensor comprises a multi-axis accelerometer.

14. A method as in claim 12, comprising calibrating the position sensor to orientation and/or activity levels of the patient.

15. A method as in claim 11, further comprising implanting an electrode connector coupleable with the electrode.

16. A method as in claim 11, further comprising implanting a pulse generator coupleable with the electrode.

17. A method as in claim 16, further comprising implanting a battery separate from the pulse generator and electrically connecting the battery to the pulse generator.

18. A method as in claim 16, wherein implanting the pulse generator comprises implanting the pulse generator in proximity to the dorsal root ganglion.

19. A method as in claim 18, wherein implanting the pulse generator comprises implanting the pulse generator in an upper back of the patient near the C1-C3 levels.

20. A method as in claim 16, further comprising implanting another pulse generator and electrically connecting the battery to the other pulse generator.

21. A method of stimulating a dorsal root ganglion according to claim 11 the activating step further comprising:

activating the electrode to stimulate a portion of the dorsal root ganglion without activation of a ventral root on the same spinal level.

22. A system for stimulating a dorsal root ganglion of a patient comprising:

a delivery device advanceable into a closest foramen to the dorsal root ganglion from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion; and

a lead having an electrode implantable on, in or about the dorsal root ganglion, wherein the lead is advanceable through the delivery device.

23. A method of stimulating a dorsal root ganglion on a first side of a spinal column, the method comprising:

advancing an electrode substantially adjacent to a portion of a peripheral nerve along the first side of the spinal column toward the dorsal root ganglion;

implanting the electrode in proximity to the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

24. A method of stimulating a dorsal root ganglion of a patient comprising:

inserting a delivery device into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion;

advancing the electrode through the delivery device without crossing a midline of a spinal column;

implanting the electrode on, in or about the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

25. A system for stimulating a dorsal root ganglion of a patient comprising:

a delivery device configured to be advanceable into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion; and

a lead having an electrode, wherein the lead is configured to be advanceable through the delivery device without crossing a midline of a spinal column and implantable on, in or about the dorsal root ganglion.

26. A method of stimulating a dorsal root ganglion comprising:

advancing an electrode substantially adjacent to a portion of a peripheral nerve toward the dorsal root ganglion without entering a spinal column;

implanting the electrode in proximity to the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

27. A method of stimulating a dorsal root ganglion of a patient comprising:

inserting a delivery device into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion;

advancing an electrode through the delivery device;

implanting the electrode on, in or about the dorsal root ganglion without entering a spinal column; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

28. A system for stimulating a dorsal root ganglion of a patient comprising:

a delivery device configured to be advanceable into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion; and

a lead having an electrode, wherein the lead is configured to be advanceable through the delivery device without entering a spinal column and implantable on, in or about the dorsal root ganglion.

29. A method of stimulating a dorsal root ganglion comprising:

advancing an electrode substantially adjacent to a portion of a peripheral nerve toward a closest foramen to the dorsal root ganglion from outside of a spinal column;

implanting the electrode in proximity to the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion without activating a ventral root on the same spinal level as the dorsal root ganglion.

30. A method of stimulating a dorsal root ganglion of a patient comprising:

inserting a delivery device into a closest foramen to the dorsal root ganglion from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion;

advancing an electrode through the delivery device;

implanting the electrode on, in or about the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

31. A method of stimulating a dorsal root ganglion comprising:

advancing an electrode substantially adjacent to a portion of a peripheral nerve toward the dorsal root ganglion without entering an epidural space;

implanting the electrode in proximity to the dorsal root ganglion; and

activating the electrode to stimulate a portion of the dorsal root ganglion.

32. A system for stimulating a dorsal root ganglion of a patient comprising:

a delivery device advanceable into a foramen from outside of a spinal column so that the delivery device is directed toward the dorsal root ganglion without entering an epidural space; and

a lead having an electrode implantable on, in or about the dorsal root ganglion, wherein the lead is advanceable through the delivery device.