Heated mechanical detachment for delivery of therapeutic devices

• US 7,582,101 B2
• Filed: 02/28/2006
• Issued: 09/01/2009
• Est. Priority Date: 02/28/2006
• Status: Expired due to Fees

• Current Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Original Assignee: Cordis Development Corporation
• Inventors: Mitelberg, Vladimir, Jones, Donald K.
• Primary Examiner(s): Manahan; Todd E
• Assistant Examiner(s): TAYLOR III, LEANDER THOMAS
• Application Number:
  US11/363,775
• Publication Number:
  US 20070203518A1
• Time in Patent Office: 1,281 Days
• Field of Search: 606/200, 623/1.11, 623/1.18
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 2017/00411 actuated by application of energy from an energy source outside the body
• CPC Class Codes: A61B 2017/00862 elastic or resilient for sutures A61B2017/0618
• CPC Class Codes: A61B 2017/12072 the heat created by laser light
• CPC Class Codes: A61B 2017/12077 Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory

Abstract

The disclosure describes apparatuses and methods for the luminal delivery of therapeutic devices. The apparatus includes a decoupling assembly comprising a retention element, a energy-responsive element and a thermally sensitive element. The application of heat to the thermally sensitive element alters its configuration such that it no longer maintains the retention element in engagement with the therapeutic device, releasing the therapeutic device.

Claims

1. An system for the endoluminal delivery of a therapeutic device, comprising:

a therapeutic device having a proximal end portion and a distal end portion;

a pusher element sized and shaped for intraluminal delivery, said pusher element having a distal end portion;

a decoupling assembly attached to said distal end portion of said pusher, said decoupling assembly including an energy-responsive element;

said decoupling assembly including a retention element having an offset orientation at which the retention element retains said therapeutic device, said retention element also having a generally collapsed orientation;

said decoupling assembly further including a thermally-responsive element having an expanded configuration that maintains said retention element in said offset orientation and having an altered configuration that does not maintain said retention element in said offset orientation;

said thermally-responsive element, retention element and energy-responsive element are designed, sized and shaped relative to each other such that said thermally-responsive element assumes said altered configuration when energy is transmitted to said energy-responsive element and said retention element moves to its said collapsed orientation and no longer retains said therapeutic device; and

a membrane encapsulating said thermally-responsive element.

2. The system of claim 1, wherein said therapeutic device is an embolic coil.

3. The system of claim 1, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of at least about 40°

C.

4. The system of claim 1, wherein said thermally-responsive element is formed from a material that changes its form at when heated to a temperature of from about 40°

C. to about 50°

C.

5. The system of claim 1, wherein said energy-responsive element is heated by an energy source selected from the group consisting of electrical, laser light, ultrasonic or radiofrequency.

6. The system of claim 1, wherein said pusher is electrically conductive and wherein said pusher is in communication with said energy-responsive element.

7. The system of claim 1, wherein said pusher member further comprises a lumen, and wherein electrical wires are disposed within said lumen and said wires are in communication with said energy-responsive element and said energy source.

8. The system of claim 1, wherein a fibre optic cable is disposed within a lumen of the pusher member and said cable is in communication with said energy-responsive element and said energy source.

9. The system of claim 1, further including an ultrasonic conductor in communication with said energy-responsive element and said energy source.

10. The system of claim 1, wherein said energy-responsive element is heated by energy transmitted in wireless fashion to said energy-responsive element through the body of a patient.

11. The apparatus of claim 1, wherein said thermally-responsive element is formed from a material selected from the group consisting of low temperature solder, hot melt adhesives, waxes and low melting point metals.

12. A decoupling assembly for engagement and release of a therapeutic device, comprising:

an energy-responsive element;

a retention element having an offset orientation that maintains a therapeutic device and has a generally collapsed orientation;

a thermally-responsive element having an expanded configuration that maintains said retention element in said offset orientation and having an altered configuration that does not maintain said retention element in said offset orientation;

said thermally-responsive element, retention element and energy-responsive element are sized and shaped relative to each other such that said thermally-responsive element assumes said altered configuration when energy is transmitted to said energy-responsive element and said retention element moves to its said collapsed orientation; and

said thermally-responsive element is formed from a material selected from the group consisting of low temperature solder, hot melt adhesives, waxes and low melting point metals.

13. The system of claim 12, further comprising a membrane encapsulating said thermally-responsive element.

14. The apparatus of claim 12, further including a material encapsulating said thermally-responsive element.

15. The apparatus of claim 12, wherein said retention element is formed from a resilient material.

16. The apparatus of claim 12, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of at least about 40°

C.

17. The apparatus of claim 12, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of from about 40°

C. to about 50°

C. and above.

18. The apparatus of claim 12, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of from about 43°

C. to about 47°

C.

19. An system for the endoluminal delivery of a therapeutic device, comprising:

an embolic coil therapeutic device having a proximal end portion and a distal end portion;

a pusher element sized and shaped for intraluminal delivery, said pusher element having a distal end portion;

a decoupling assembly attached to said distal end portion of said pusher, said decoupling assembly including an energy-responsive element;

said decoupling assembly including a retention element having an offset orientation at which the retention element retains said therapeutic device, said retention element also having a generally collapsed orientation;

said decoupling assembly further including a thermally-responsive element having an expanded configuration that maintains said retention element in said offset orientation and having an altered configuration that does not maintain said retention element in said offset orientation;

said thermally-responsive element, retention element and energy-responsive element are designed, sized and shaped relative to each other such that said thermally-responsive element assumes said altered configuration when energy is transmitted to said energy-responsive element and said retention element moves to its said collapsed orientation and no longer retains said therapeutic device; and

said thermally-responsive element is formed from a material selected from the group consisting of low temperature solder, hot melt adhesives, waxes and low melting point metals.

20. The system of claim 19, wherein said thermally-responsive element is formed from a material that changes its form at when heated to a temperature of from about 40°

C. to about 50°

C.

21. The system of claim 19, wherein said energy-responsive element is heated by an energy source selected from the group consisting of electrical, laser light, ultrasonic or radio frequency.

22. The system of claim 19, wherein said pusher is electrically conductive and wherein said pusher is in communication with said energy-responsive element.

23. The system of claim 19, wherein said pusher member further comprises a lumen, and wherein electrical wires are disposed within said lumen and said wires are in communication with said energy-responsive element and said energy source.

24. The system of claim 19, wherein a fibre optic cable is disposed within a lumen of the pusher member and said cable is in communication with said energy-responsive element and said energy source.

25. The system of claim 19, further including an ultrasonic conductor in communication with said energy-responsive element and said energy source.

26. The system of claim 19, wherein said energy-responsive element is heated by energy transmitted in wireless fashion to said energy-responsive element through the body of a patient.

27. A decoupling assembly for engagement and release of a therapeutic device, comprising:

an energy-responsive element;

a retention element having an offset orientation that maintains a therapeutic device and has a generally collapsed orientation;

a thermally-responsive element having an expanded configuration that maintains said retention element in said offset orientation and having an altered configuration that does not maintain said retention element in said offset orientation;

said thermally-responsive element, retention element and energy-responsive element are sized and shaped relative to each other such that said thermally-responsive element assumes said altered configuration when energy is transmitted to said energy-responsive element and said retention element moves to its said collapsed orientation; and

a material encapsulating said thermally-responsive element.

28. The apparatus of claim 27, wherein said retention element is formed from a resilient material.

29. The apparatus of claim 27, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of from about 40°

C. to about 50°

C. and above.

30. The apparatus of claim 27, wherein said thermally-responsive element is formed from a material that changes its form when heated to a temperature of from about 43°

C.to about 47°

C.