Medical uses of intercellular communication facilitating compounds

• US 7,585,839 B2
• Filed: 08/22/2003
• Issued: 09/08/2009
• Est. Priority Date: 02/23/2000
• Status: Expired due to Fees

• Current Assignee: Zealand Pharma A/S
• Original Assignee: Zealand Pharma A/S
• Inventors: Kjolbye, Anne Louise, Jorgensen, Niklas Rye, Holstein-Rathlou, Neils-Henrik, Neilsen, Morten Schak, Jensen, Peter Holme, Larsen, Bjarne Due, Meier, Eddi, Petersen, Jorgen Soberg, Martins, James B.
• Primary Examiner(s): Tate; Christopher R.
• Assistant Examiner(s): TELLER, ROY R
• Application Number:
  US10/646,294
• Publication Number:
  US 20050113293A1
• Time in Patent Office: 2,209 Days
• Field of Search: None
• US Class Current: 514/1.1
• CPC Class Codes: A61K 31/365 Lactones
• CPC Class Codes: A61K 31/551 having two nitrogen atoms, e.g. dilazep
• CPC Class Codes: A61K 38/12 Cyclic peptides , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 47/645 Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Abstract

Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.

Claims

1. A compound selected from the group consisting of hydroxyacetyl-Asn-Tyr-NH₂, hydroxyacetyl-Asn-Tyr-OH, hydroxyacetyl-Gly-Tyr-NH₂, and hydroxyacetyl-Gly-Tyr-OH;

or a pharmaceutically acceptable salt thereof.

2. A phamaceutical composition comprising:

(a) a compound of claim 1 or a pharmaceutically acceptable salt thereof; and

(b) a pharmaceutically acceptable carrier or diluent.

3. The pharmaceutical composition of claim 2, wherein said composition is in a form suitable for oral or parenteral administration.

4. The pharmaceutical composition of claim 3, wherein said form suitable for oral administration is an enteric tablet.

5. Hydroxyacetyl-Asn-Tyr-NH₂, or a pharmaceutically acceptable salt thereof.

6. A pharmaceutical composition comprising:

(a) the compound of claim 5, or a pharmaceutically acceptable salt thereof; and

(b) a pharmaceutically acceptable carrier or diluent.

7. The pharmaceutical composition of claim 6, wherein said composition is in a form suitable for oral or parenteral administration.

8. The pharmaceutical composition of claim 7, wherein said form suitable for oral administration is an enteric tablet.

9. Hydroxyacetyl-Asn-Tyr-OH, or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising:

(a) the compound of claim 9, or a pharmaceutically acceptable salt thereof; and

(b) a pharmaceutically acceptable carrier or diluent.

11. The pharmaceutical composition of claim 10, wherein said composition is in a form suitable for oral or parenteral administration.

12. The pharmaceutical composition of claim 11, wherein said form suitable for oral administration is an enteric tablet.

13. Hydroxyacetyl-Gly-Tyr-NH₂, or a pharmaceutically acceptable salt thereof.

14. A pharmaceutical composition comprising:

(a) the compound of claim 13, or a pharmaceutically acceptable salt thereof; and

(b) a pharmaceutically acceptable carrier or diluent.

15. The pharmaceutical composition of claim 14, wherein said composition is in a form suitable for oral or parenteral administration.

16. The pharmaceutical composition of claim 15, wherein said form suitable for oral administration is an enteric tablet.

17. Hydroxyacetyl-Gly-Tyr-OH, or a pharmaceutically acceptable salt thereof.

18. A pharmaceutical composition comprising:

(a) the compound of claim 17, or a pharmaceutically acceptable salt thereof; and

(b) a pharmaceutically acceptable carrier or diluent.

19. The pharmaceutical composition of claim 18, wherein said composition is in a form suitable for oral or parenteral administration.

20. The pharmaceutical composition of claim 19, wherein said form suitable for oral administration is an enteric tablet.