Optical spectroscopy for the detection of ischemic tissue injury
First Claim
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1. A method, comprising:
- illuminating a surface area of tissue with a first beam of light from a first substantially narrow spectral band source to produce an illuminated surface area, wherein said first beam of light is delivered from the distal end of an illumination transporting optic, including said distal end, wherein said distal end does not make contact with said tissue, wherein said illuminated surface area is larger than about 1.5 mm2, wherein said first beam of light induces a first autofluorescence emission from said surface area;
illuminating at least part of said surface area with a second beam of light from a second substantially narrow spectral band source, wherein said second beam of light is delivered from said distal end, wherein said second beam of light induces a second autofluorescence emission from said surface area;
detecting said first autofluorescence emission and said second autofluorescense emission; and
comparing said first autofluorescence emission to said second autofluorescense emission to assess in real-time a property of said tissue.
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Abstract
An optical method and apparatus is utilized to quantify ischemic tissue and/or organ injury. Such a method and apparatus is non-invasive, non-traumatic, portable, and can make measurements in a matter of seconds. Moreover, such a method and apparatus can be realized through optical fiber probes, making it possible to take measurements of target organs deep within a patient'"'"'s body. Such a technology provides a means of detecting and quantifying tissue injury in its early stages, before it is clinically apparent and before irreversible damage has occurred.
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Citations
54 Claims
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1. A method, comprising:
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illuminating a surface area of tissue with a first beam of light from a first substantially narrow spectral band source to produce an illuminated surface area, wherein said first beam of light is delivered from the distal end of an illumination transporting optic, including said distal end, wherein said distal end does not make contact with said tissue, wherein said illuminated surface area is larger than about 1.5 mm2, wherein said first beam of light induces a first autofluorescence emission from said surface area; illuminating at least part of said surface area with a second beam of light from a second substantially narrow spectral band source, wherein said second beam of light is delivered from said distal end, wherein said second beam of light induces a second autofluorescence emission from said surface area; detecting said first autofluorescence emission and said second autofluorescense emission; and comparing said first autofluorescence emission to said second autofluorescense emission to assess in real-time a property of said tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An apparatus for assessing tissue parameters, comprising:
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a first source of electromagnetic radiation configured to produce a first beam of light having a substantially narrow spectral band; a second source of electromagnetic radiation configured to produce a second beam of light having a substantially narrow spectral band; an illumination transporting optic, comprising a distal end, wherein said conduit is adapted for directing said first beam of light and said second beam of light to illuminate from said distal end, a surface area of a tissue to produce an illuminated surface area, wherein said illuminated surface area is larger than about 1.5 mm2, wherein said first beam of light induces a first autofluorescence emission from said surface area and wherein said second beam of light induces a second autofluorescence emission, wherein said conduit further comprises means for receiving and directing said first autofluorescence emission and said second autofluorescence emission; a spacer fixedly attached to said distal end to place said distal end in a position that is not touching said tissue; a device adapted to record said first autofluorescence emission and said second au tofluorescence emission; and means for comparing said first autofluorescence emission and said second autofluorescence emission to assess in real-time a property of said tissue. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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Specification