Brachytherapy apparatus for dispensing medication

• US 7,588,528 B2
• Filed: 08/24/2004
• Issued: 09/15/2009
• Est. Priority Date: 08/24/2004
• Status: Active Grant

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Drobnik, Michael W., Drobnik, Christopher D.
• Primary Examiner(s): Lacyk; John P
• Application Number:
  US10/924,441
• Publication Number:
  US 20060063961A1
• Time in Patent Office: 1,848 Days
• Field of Search: 600 1- 8
• US Class Current: 600/3
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

An applicator system for interstitial radiation therapy that uses a brachytherapy needle assembly for simultaneously dispensing an effective amount of medicine, such as anti-inflammatory agents, along with radioactive seeds. A medicine cartridge or a modified seed cartridge, having a reservoir on its proximal end, can be attached to the applicator body for dispensing medicine into a needle or medicine can be injected into the needle via a three-way fitting attached to the applicator body. Alternatively, a modified stylet having a reservoir on its proximal end containing medicine can be used to deliver medication to a needle. Additionally, the brachytherapy needle or the radioactive seeds and spacers can be coated with medication that would be absorbed by the body upon implantation.

Claims

1. A method of performing a brachytherapy procedure with an applicator system comprising a needle and a seed cartridge attached to the needle, the method comprising:

inserting a brachytherapy needle having a lumen into a desired location in a patient along an insertion path extending from a proximal initial insertion point to a distal needle endpoint;

dispensing at least one radiation source from the seed cartridge into the lumen of the brachytherapy needle, then from the brachytherapy needle to a location in the insertion path; and

dispensing medication, separate from said at least one radiation source, from the lumen of the brachytherapy needle to a location in the insertion path before the brachytherapy needle is removed from the insertion path.

2. The method of claim 1, wherein the medication comprises an anti-inflammatory material.

3. The method of claim 1, wherein the medication comprises an anesthetic.

4. The method of claim 1, further comprising dispensing medication from a second cartridge to the needle for dispensing to the insertion path.

5. The method of claim 1, further comprising dispensing liquid medication from a reservoir coupled to a three-way fitting attached to a chuck of the needle.

6. The method of claim 1, further comprising coating the needle with medication.

7. The method of claim 1, further comprising dispensing medication from said seed cartridge, said seed cartridge having a medicine reservoir for holding and dispensing said medication and at least one radiation source into a chuck of the needle.

8. The method of claim 1, wherein the applicator system comprises a hollow stylet having a reservoir in fluid communication with the proximal end of the stylet, wherein the step of dispensing the at least one radiation source from the seed cartridge into the lumen of the brachytherapy needle, then from the brachytherapy needle to the location in the insertion path comprises:

moving the hollow stylet within the lumen of the brachytherapy needle to push the at least one radiation source through the lumen of the brachytherapy needle to the location in the insertion path;

wherein the step of dispensing the medication comprises;

dispensing the medication from the hollow stylet and into the lumen of the brachytherapy needle.

18. The method of claim 1, wherein the medication is dispensed at least one of before, concurrently with, and after said at least one radiation source.

9. A brachytherapy applicator system, comprising:

a brachytherapy needle having a lumen, a needle chuck coupled to a proximal end of the brachytherapy needle, a radiation source cartridge coupled to said coupled chuck and needle, and a stylet adapted to push a seed through the lumen, said radiation source cartridge being adapted to dispense seeds into the coupled chuck and needle, one seed at a time, said stylet being adapted to push the seed through the lumen and then retract proximal of the cartridge; and

a medication dispensing structure comprising a reservoir constructed to store liquid medication in fluid communication with the lumen of the brachytherapy needle, the system being constructed and arranged to separately dispense both said liquid medication and seeds to substantially the same location in a patient, through the lumen of the brachytherapy needle, without removing the brachytherapy needle from the patient.

10. The brachytherapy system of claim 9, wherein the reservoir contains medication comprising anti-inflammatory material.

11. The brachytherapy system of claim 9, wherein the reservoir contains medication comprising anesthetic.

12. The brachytherapy system of claim 9, wherein the stylet comprises a hollow shaft and is sized to fit within the lumen so that sources can be dispensed by moving the stylet relative to the lumen, wherein the reservoir is joined to the stylet and is in fluid communication with the hollowed portion of the stylet to dispense medication through the stylet.

13. The brachytherapy system of claim 9, wherein the needle has a three-way fitting attached to the needle chuck and the reservoir is in fluid communication with the lumen through the three-way fitting.

14. The brachytherapy system of claim 9, wherein the needle is coated with medication.

15. The brachytherapy system of claim 9, wherein the needle comprises a dual lumen and one lumen is sized and positioned to receive radioactive sources from the cartridge and the second lumen is in fluid communication with the reservoir storing medication.

16. The brachytherapy system of claim 9, wherein a second cartridge for holding and dispensing medication is attached to the needle chuck.

17. The brachytherapy system of claim 9, wherein said radiation source cartridge further comprises a medicine reservoir for holding and dispensing medication and at least one radiation source into the needle chuck.

19. A method of performing a brachytherapy procedure with an applicator system comprising a needle and a seed cartridge attached to the needle, the method comprising:

inserting a brachytherapy needle having a lumen into a desired location in a patient along an insertion path extending from a proximal initial insertion point to a distal needle endpoint;

dispensing at least one radiation source from the cartridge into the brachytherapy needle, then from the needle to a location in the insertion path; and

flowing liquid medication through said lumen, separate from the at least one radiation source, to a location in the insertion path before the brachytherapy needle is removed from the insertion path.

20. A brachytherapy applicator system, comprising:

a brachytherapy needle having a lumen, a needle chuck coupled to a proximal end of the needle, a radiation source cartridge coupled to said coupled chuck and needle, and a stylet configured to push a seed through the lumen, said radiation source cartridge being constructed and arranged to dispense seeds into said coupled chuck and needle, one seed at a time, said stylet being adapted to push the seed through the lumen and then retract proximal of the cartridge; and

a medication dispensing structure comprising a reservoir constructed to store liquid medication in fluid communication with the lumen, the system being constructed and arranged to direct said liquid medication to coat a seed as said seed is pushed through the lumen by the stylet.

21. A brachytherapy applicator system, comprising:

a brachytherapy needle having a lumen, a needle chuck coupled to a proximal end of the needle, a radiation source cartridge coupled to said coupled chuck and needle, and a stylet configured to push a seed through the lumen, said radiation source cartridge being constructed and arranged to dispense seeds into said coupled chuck and needle, one at a time, said stylet being adapted to push the seed through the lumen and then retract proximal of the cartridge; and

a medication dispensing structure comprising a reservoir constructed to store medication in communication with the lumen, the system being constructed and arranged to dispense said liquid medication, separate from said seeds, to substantially the same location in a patient, through the lumen, without removing the needle from the patient.

22. The brachytherapy system of claim 21, wherein the system is configured to dispense said medication into the patient.