Apparatus for piezoelectric layer-wise pump and valve for use in local administration of biological response modifiers and therapeutic agents
First Claim
1. An implantable apparatus for infusing a plurality of medicating agents to a specific desired location at a tumor site for nonsystemic treatment of a tumor, when implanted within a patient'"'"'s body, comprising:
- an implantable pouch having a plurality of collapsible and disintegratable chambers composed of a bioabsorbable material, the pouch comprising a scaffolding forming a matrix capable of degrading over time, and a synthetic human skin for substantially enclosing the pouch, the chambers being structurally defined by the matrix, each chamber having a volume for storing a corresponding one of the plurality of the medicating agents in a macroscopic amount and for a duration effective for tumor treatment including relatively long durations, and wherein the chambers and the synthetic human skin are arranged and configured to substantially completely collapse and disintegrate within the patient'"'"'s body with depletion of the plurality of medicating agents which is selectively dispensed from the chambers;
where the plurality of medicating agents are stored in corresponding ones of the plurality of collapsible chambers;
multiple implantable piezoelectric pumps fabricated in the pouch which pumps form a skeleton for the pouch, the pumps being configured to transfer the medicating agents to the patient;
where the synthetic human skin is an implantable and bioabsorbable skin substitute;
at least one implanted sensor to measure a local homeostatic response related to at least one of the plurality of medicating agents; and
an implanted control circuit with a programmable memory on a biodegradable substrate housed within and implanted at the site of implantation of the pouch and proximate to the pumps to control optimal local dosing amounts of each of the medicating agents and scheduling of the medicating agents in a closed loop control mode so that control of the operation is performed autonomously as determined by adjustable values of locally sensed homeostatic parameters at the treatment site,where the control circuit controls at least one of the piezoelectric pumps to modify the state of the tumor in response to measurements from the implanted sensor, and where the control circuit controls and selectively adjusts the scheduling of the amounts of the medicating agents which are delivered in response to selective user commands delivered to the control circuit and alterable during a treatment process after implantation.
3 Assignments
0 Petitions
Accused Products
Abstract
A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of anti-tumor agents in a local setting is provided. In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery. In one embodiment, reporting the events in the tumor site via an RF link to the external control box is provided.
10 Citations
56 Claims
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1. An implantable apparatus for infusing a plurality of medicating agents to a specific desired location at a tumor site for nonsystemic treatment of a tumor, when implanted within a patient'"'"'s body, comprising:
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an implantable pouch having a plurality of collapsible and disintegratable chambers composed of a bioabsorbable material, the pouch comprising a scaffolding forming a matrix capable of degrading over time, and a synthetic human skin for substantially enclosing the pouch, the chambers being structurally defined by the matrix, each chamber having a volume for storing a corresponding one of the plurality of the medicating agents in a macroscopic amount and for a duration effective for tumor treatment including relatively long durations, and wherein the chambers and the synthetic human skin are arranged and configured to substantially completely collapse and disintegrate within the patient'"'"'s body with depletion of the plurality of medicating agents which is selectively dispensed from the chambers; where the plurality of medicating agents are stored in corresponding ones of the plurality of collapsible chambers; multiple implantable piezoelectric pumps fabricated in the pouch which pumps form a skeleton for the pouch, the pumps being configured to transfer the medicating agents to the patient; where the synthetic human skin is an implantable and bioabsorbable skin substitute; at least one implanted sensor to measure a local homeostatic response related to at least one of the plurality of medicating agents; and an implanted control circuit with a programmable memory on a biodegradable substrate housed within and implanted at the site of implantation of the pouch and proximate to the pumps to control optimal local dosing amounts of each of the medicating agents and scheduling of the medicating agents in a closed loop control mode so that control of the operation is performed autonomously as determined by adjustable values of locally sensed homeostatic parameters at the treatment site, where the control circuit controls at least one of the piezoelectric pumps to modify the state of the tumor in response to measurements from the implanted sensor, and where the control circuit controls and selectively adjusts the scheduling of the amounts of the medicating agents which are delivered in response to selective user commands delivered to the control circuit and alterable during a treatment process after implantation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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Specification