Method and device for anastomoses

• US 7,588,565 B2
• Filed: 05/15/2003
• Issued: 09/15/2009
• Est. Priority Date: 05/15/2002
• Status: Expired due to Fees

• Current Assignee: Rocky Mountain Biosystems, Inc.
• Original Assignee: Rocky Mountain Biosystems, Inc.
• Inventors: Marchitto, Kevin S., Flock, Stephen T.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US10/438,514
• Publication Number:
  US 20030236518A1
• Time in Patent Office: 2,315 Days
• Field of Search: 606 27- 31, 606/41, 606213-216, 600/13, 607 98-101
• US Class Current: 606/27
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/085 Forceps, scissors
• CPC Class Codes: A61B 2018/00345 Vascular system
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00619 Welding

Abstract

Provided herein is a device for use in an anastomosis of tissue(s) comprising a biocompatible material and a means of applying radiofrequency energy or electrical energy to generate heat within said biocompatible material. The device also may be used to bond or fuse at two materials where at least one of the material is a tissue. Also provided are methods to anastomose tissue or to bond or to fuse these materials using these devices.

Claims

1. A device for creating an anastomosis of tissue(s) comprising:

a fusable biocompatible material;

a conductive material combined with the biocompatible material,

at least one induction coil disposed in relation to the biocompatible material such that a radiofrequency-induced oscillating magnetic field generates heat around the biocompatible material to fuse or bond at least two materials and create anastomosis of tissue(s); and

a glass envelope containing a cooling fluid and said induction coil(s).

2. The device of claim 1, wherein said biocompatible material complements tissue geometry to bond or fuse at least two materials wherein at least one material is a tissue.

3. The device of claim 1, wherein said biocompatible material is a liquid, a solid or a semi-solid.

4. The device of claim 1, wherein said biocompatible material comprises a protein, a biocompatible polymer, polymeric matrix substance, or a combination thereof.

5. The device of claim 4, wherein said protein is elastin, albumin, fibrin, collagen, or glycoprotein.

6. The device of claim 4, wherein said polymeric substance is hydrogel, agar or sol-gel.

7. The device of claim 4, wherein said biocompatible material further comprises a pharmaceutical.

8. The device of claim 7, wherein said pharmaceutical is an anti-coagulant, an antithrombotic, an antibiotic, a hormone, a steroidal antiinflammatory agent, a non-steroidal antiinflammatory agent, an anti-viral agent or an anti-fungal agent, or a combination thereof.

9. The device of claim 1, wherein said cooling fluid is low viscosity mineral oil or water.

10. The device of claim 1, wherein said induction coils further comprise a coating of a smooth non-adhering material.

11. The device of claim 1, wherein said non-adhering material comprises polytetrafluoroethylene, titanium or gold.

12. The device of claim 1, wherein the conductive material has a thermal history such that application of the oscillating magnetic field to said conductive material generates an estimable amount of heat.

13. The device of claim 1, wherein said conductive material is a metal wire, a metal particle, a ferromagnetic material, a paramagnetic material, a conducting polymer, an ionic molecule, a polar molecule or a conducting microsphere.

14. The device of claim 1, wherein said conductive material is an energy-absorbing material, said energy-absorbing material comprising conducting polystyrene microbeads, a colloidal metal, a conducting polymer, a strongly ionic molecule or a strongly polar molecule.

15. A method for performing an anastomosis between at least two tissues comprising the steps of:

positioning the device of claim 1 around said tissues, said tissues simultaneously in contact with the biocompatible material of said device and with each other;

applying a radiofrequency-induced oscillating magnetic field to said biocompatible material;

thereby generating heat within one or both of said biocompatible material or conductive material and said tissues, said heating adhering said biocompatible materiel to said tissues, or adhering said tissues to each other, thereby anastomosing said tissues.

16. The method of claim 15, wherein adherence of said biocompatible material to said tissues or adherence of said tissues results from molecular changes in said biocompatible material and in said tissues.

17. A device for fusing at least two materials, whereby at least one material is tissue, comprising:

a fusable biocompatible material;

at least one induction coil disposed in relation to the biocompatible material such that a radiofrequency-induced oscillating magnetic field generates around the biocompatible material;

a glass envelope containing cooling fluid and said induction coil(s); and

means for controlling output of the heat generated within said biocompatible material and combined therewithin.

18. The device of claim 17, wherein said biocompatible material complements tissue geometry.

19. The device of claim 17, wherein said biocompatible material is a liquid, a solid or a semi-solid.

20. The device of claim 17, wherein said biocompatible material comprises a protein, a biocompatible polymer, polymeric matrix substance, or a combination thereof.

21. The device of claim 20, wherein said protein is elastin, albumin, fibrin, collagen, or glycoprotein.

22. The device of claim 20, wherein said polymeric substance is hydrogel, agar or sol-gel.

23. The device of claim 20, wherein said biocompatible material further comprises a pharmaceutical.

24. The device of claim 23, wherein said pharmaceutical is an anti-coagulant, an antithrombotic, an antibiotic, a hormone, a steroidal antiinflammatgry agent, a non-steroidal antiinflammatory agent, an anti-viral agent or an antifungal agent, or a combination thereof.

25. The device of claim 17, wherein said cooling fluid is low viscosity mineral oil or water.

26. The device of claim 17, said induction coils further comprising a coating of a smooth non-adhering material.

27. The device of claim 26, wherein said non-adhering material comprises teflon, titanium or gold.

28. The device of claim 17, wherein the means for controlling output of heat conducted to said tissues is a conductive material in contact with said biocompatible material, said conductive material having a thermal history such that application of the oscillating magnetic field to said conductive material generates an estimable amount of heat.

29. The device of claim 28, wherein said conductive material is a metal wire, a metal particle, a ferromagnetic material, a paramagnetic material, a conducting polymer, an ionic molecule, a polar molecule or a conducting microsphere.

30. The device of claim 28, wherein said conductive material is an energy-absorbing material, said energy-absorbing material comprising conducting polystyrene microbeads, a colloidal metal, a conducting polymer, a strongly ionic molecule or a strongly polar molecule.

31. A method for fusing two materials, whereby at least one is tissue, comprising the steps of:

positioning the device of claim 17 around said materials, said materials simultaneously in contact with the biocompatible material of said device and with each other;

applying a radiofrequency-induced oscillating magnetic field to said biocompatible material;

generating heat within said biocompatible material; and

controlling output of heat to said materials to be fused via the heat controlling means of said device, said output of heat fusing said materials together.

32. The method of claim 31, wherein bonding of said biocompatible material to said materials or fusing said materials together results from molecular changes in said biocompatible material and in said materials.