Optical lens system and method for microfluidic devices
DCFirst Claim
1. An apparatus for imaging a microfluidic device comprising a plurality of processing sites, the apparatus comprising:
- an illumination system coupled to the microfluidic device and adapted to illuminate the microfluidic device with electromagnetic radiation, wherein the microfluidic device is characterized by a device dimension about 30.7 mm by about 30.7 mm or greater, the device dimension including the plurality of processing sites;
an imaging system coupled to the microfluidic device and adapted to simultaneously receive electromagnetic radiation emitted from the plurality of processing sites; and
a detector coupled to the imaging system and characterized by a detection area less than the device dimension.
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Abstract
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluorescent emission signals derived from one or more samples in the at least one chamber of the at least one microfluidic device. The chamber has a chamber size, the chamber size being characterized by an actual spatial dimension normal to the imaging path. The apparatus also includes an optical lens system coupled to the imaging path. The optical lens system is adapted to transmit the one or more fluorescent signals associated with the chamber.
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Citations
40 Claims
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1. An apparatus for imaging a microfluidic device comprising a plurality of processing sites, the apparatus comprising:
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an illumination system coupled to the microfluidic device and adapted to illuminate the microfluidic device with electromagnetic radiation, wherein the microfluidic device is characterized by a device dimension about 30.7 mm by about 30.7 mm or greater, the device dimension including the plurality of processing sites; an imaging system coupled to the microfluidic device and adapted to simultaneously receive electromagnetic radiation emitted from the plurality of processing sites; and a detector coupled to the imaging system and characterized by a detection area less than the device dimension. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. An apparatus for imaging a microfluidic device comprising more than 96 closed reaction chambers, the apparatus comprising:
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an illumination system coupled to the microfluidic device and adapted to illuminate the microfluidic device with electromagnetic radiation, wherein the microfluidic device is characterized by a device dimension including the more than 96 closed reaction chambers; an imaging system coupled to the microfluidic device and adapted to simultaneously receive electromagnetic radiation emitted from the more than 96 closed reaction chambers; and a detector coupled to the imaging system and characterized by a detection area less than the device dimension. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for imaging a microfluidic device comprising a plurality of processing sites, the apparatus comprising:
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an illumination system coupled to the microfluidic device and adapted to illuminate the microfluidic device with electromagnetic radiation, wherein the microfluidic device is characterized by a device dimension including the plurality of processing sites; an imaging system coupled to the microfluidic device and adapted to simultaneously receive a fluorescent signal emitted from the plurality of processing sites; a detector coupled to the imaging system and characterized by a detection area less than the device dimension; and a thermal controller coupled to the microfluidic device. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30)
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31. An apparatus for imaging a microfluidic device comprising a plurality of processing sites, the apparatus comprising:
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an illumination system coupled to the microfluidic device and adapted to illuminate the microfluidic device with electromagnetic radiation, wherein the microfluidic device is characterized by a device dimension including the plurality of processing sites; an imaging system coupled to the microfluidic device and adapted to simultaneously receive electromagnetic radiation emitted from the plurality of processing sites; and a detector coupled to the imaging system and characterized by a detection area including a pixel region having at least 2048 pixels by 2048 pixels, wherein the detection area is less than the device dimension. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification