×

Reagent sets and gene signatures for renal tubule injury

  • US 7,588,892 B2
  • Filed: 07/18/2005
  • Issued: 09/15/2009
  • Est. Priority Date: 07/19/2004
  • Status: Expired due to Fees
First Claim
Patent Images

1. A method for testing whether a compound will induce renal tubule injury in a test subject, the method comprising:

  • a) administering a dose of compound to at least one test subject, wherein the test subject is a mouse or rat;

    b) after a selected time period, obtaining a biological sample from the at least one test subject;

    c) measuring the expression levels in the biological sample of at least a plurality of sequences selected from Table 4, wherein the plurality of sequences comprises AI105417, BF404557, U08257, BF285022, and AF155910 and has at least 2% of the total impact of all of the sequences in Table 4; and

    d) determining whether the sample is in the positive class for renal tubule injury using a classifier comprising at least the plurality of sequences for which the expression levels are measured.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×