Implantable devices for accelerated healing
First Claim
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1. An implantable device comprising a protein patterning on said device, wherein the protein patterning comprises:
- (a) a protein selected from the group consisting of fibronectin, laminin 5, elastin, silk elastin, collagen and combinations thereof, and(b) an agent selected from the group consisting of an adhesion molecule that includes a RGD motif, a chemoattractant of an endothelial cell, a NO releasing or generating agent, an agent that promotes endothelialization, or combinations thereof;
and wherein the protein of (a) and the agent of (b) are chemically bonded to one another via a spacer.
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Abstract
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
339 Citations
14 Claims
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1. An implantable device comprising a protein patterning on said device, wherein the protein patterning comprises:
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(a) a protein selected from the group consisting of fibronectin, laminin 5, elastin, silk elastin, collagen and combinations thereof, and (b) an agent selected from the group consisting of an adhesion molecule that includes a RGD motif, a chemoattractant of an endothelial cell, a NO releasing or generating agent, an agent that promotes endothelialization, or combinations thereof; and wherein the protein of (a) and the agent of (b) are chemically bonded to one another via a spacer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification