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Modified nucleosides and nucleotides and uses thereof

  • US 7,592,435 B2
  • Filed: 07/27/2006
  • Issued: 09/22/2009
  • Est. Priority Date: 08/19/2005
  • Status: Active Grant
First Claim
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1. A modified nucleotide consisting of a guanine base or a 7-deazaguanine base attached to a fluorophore through a linking group, one or more phosphate groups, and a ribose or 2′

  • -deoxyribose having a blocking group attached to the 3′

    oxygen atom thereof, wherein said linking group comprises a spacer group of formula —

    ((CH2)2O)n

    wherein n is an integer between 10 and 30, and wherein the presence of the linking group reduces fluorescent signal quenching of the fluorophore by the guanine base or 7-deazaguanine base.

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