Method of determining analyte concentration in a sample using infrared transmission data
First Claim
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1. A method of determining an analyte concentration in a sample using infrared spectroscopy, the method comprising:
- providing a source of infrared radiation comprising a plurality of wavelengths and a detector responsive to infrared radiation at the plurality of wavelengths;
placing a sample in a sample element having a shape;
irradiating the sample element with infrared radiation from the source after the sample has been placed in the sample element;
detecting with the detector at least a portion of the infrared radiation transmitted through the sample element and the sample;
determining measured absorption data at the plurality of wavelengths, the measured absorption data determined based at least in part on the detected portion of the infrared radiation; and
correcting the measured absorption data to provide corrected absorption data, wherein the corrected absorption data is corrected for a non-analyte contribution that is, at least in part, from the shape of the sample element.
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Abstract
A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
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22 Claims
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1. A method of determining an analyte concentration in a sample using infrared spectroscopy, the method comprising:
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providing a source of infrared radiation comprising a plurality of wavelengths and a detector responsive to infrared radiation at the plurality of wavelengths; placing a sample in a sample element having a shape; irradiating the sample element with infrared radiation from the source after the sample has been placed in the sample element; detecting with the detector at least a portion of the infrared radiation transmitted through the sample element and the sample; determining measured absorption data at the plurality of wavelengths, the measured absorption data determined based at least in part on the detected portion of the infrared radiation; and correcting the measured absorption data to provide corrected absorption data, wherein the corrected absorption data is corrected for a non-analyte contribution that is, at least in part, from the shape of the sample element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of determining an analyte concentration, the method comprising:
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storing in a memory absorption data of a sample of body fluid disposed in a sample element having a shape, the absorption data comprising a plurality of wavelengths; transforming the absorption data into corrected absorption data using a processor configured to have access to the memory, wherein transforming comprises correcting the absorption data for a non-analyte contribution that is, at least in part, from the shape of the sample element; and calculating, with the processor, an analyte concentration in the sample of body fluid, wherein calculating is based at least in part on the corrected absorption data. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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Specification