Joint resurfacing orthopaedic implant and associated method

• US 7,595,062 B2
• Filed: 07/28/2005
• Issued: 09/29/2009
• Est. Priority Date: 07/28/2005
• Status: Active Grant

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: Depuy Products Incorporated (Johnson & Johnson)
• Inventors: Pedrozo, Hugo A., Widmer, Matthew N.
• Primary Examiner(s): Desai; Anand U
• Application Number:
  US11/192,222
• Publication Number:
  US 20070026053A1
• Time in Patent Office: 1,524 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4081 Glenoid components, e.g. cups
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30757 made of a sheet covering the natural articular surface, e.g. cap
• CPC Class Codes: A61F 2002/3092 having an open-celled or open-pored structure
• CPC Class Codes: A61F 2002/30934 Special articulating surfaces
• CPC Class Codes: A61F 2002/30971 Laminates, i.e. layered products
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61K 35/38 Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

An orthopaedic implant includes a porous structure made of a type I collagen matrix having at least one sheet of a naturally occurring extracellular matrix secured thereto. Methods of making and using such an implant are also disclosed.

Claims

1. An orthopaedic implant, comprising:

a self-assembled porous structure comprising a collagen type I matrix, wherein the self-assembled porous structure contains 75% collagen type I in its native α

-helical structure, and

at least one sheet of naturally occurring submucosal matrix secured to the self-assembled porous structure.

2. The orthopaedic implant of claim 1, wherein:

the at least one sheet of naturally occurring submucosal matrix comprises a first sheet of naturally occurring submucosal matrix and a second sheet of naturally occurring submucosal matrix, and

the self-assembled porous structure is sandwiched between the first sheet of naturally occurring submucosal matrix and the second sheet of naturally occurring submucosal matrix.

3. The orthopaedic implant of claim 2, wherein:

the first sheet of naturally occurring submucosal matrix comprises a sheet of small intestinal submucosa (SIS) and

the second sheet of naturally occurring extracellular matrix comprises a sheet of small intestinal submucosa (SIS).

4. The orthopaedic implant of claim 1, wherein:

the at least one sheet of naturally occurring submucosal matrix comprises a first plurality of sheets of naturally occurring submucosal matrix and a second plurality of sheets of naturally occurring submucosal matrix, and

the self-assembled porous structure is sandwiched between the first plurality of sheets of naturally occurring submucosal matrix and the second plurality of sheets of naturally occurring submucosal matrix.

5. The orthopaedic implant of claim 4, wherein:

the first plurality of sheets of naturally occurring submucosal matrix comprises a plurality of sheets of SIS, and

the second plurality of sheets of naturally occurring submucosal matrix comprises a plurality of sheets of SIS.

6. The orthopaedic implant of claim 1, wherein:

the at least one sheet of naturally occurring submucosal matrix comprises a first number of sheets of naturally occurring submucosal matrix and a second number of sheets of naturally occurring submucosal matrix, the first number of sheets being greater than the second number of sheets, and

the self-assembled porous structure is sandwiched between the first number of sheets of naturally occurring submucosal matrix and the second number of sheets of naturally occurring submucosal matrix.

7. The orthopaedic implant of claim 6, wherein:

the first number of sheets of naturally occurring submucosal matrix comprises a number of sheets of SIS, and

the second number of sheets of naturally occurring submucosal matrix comprises a number of sheets of SIS.

8. The orthopaedic implant of claim 1, further comprising a plurality of indentations formed in an outer surface of the implant.

9. The orthopaedic implant of claim 1, wherein:

the at least one sheet of naturally occurring submucosal matrix comprises a first number of sheets of naturally occurring submucosal matrix and a second number of sheets of naturally occurring submucosal matrix,

the self-assembled porous structure is sandwiched between the first number of sheets of naturally occurring submucosal matrix and the second number of sheets of naturally occurring submucosal matrix, and

the first number of sheets of naturally occurring submucosal matrix has a plurality of indentations formed therein.

10. The orthopaedic implant of claim 9, wherein:

the first number of sheets of naturally occurring submucosal matrix comprises a number of sheets of SIS, and

the second number of sheets of naturally occurring submucosal matrix comprises a number of sheets of SIS.

11. The orthopaedic implant of claim 1, further comprising a bioactive agent.

12. An orthopaedic device, comprising:

a resorbable orthopaedic implant configured to resurface a joint, the resorbable orthopaedic implant having a self-assembled porous structure comprising a collagen type I matrix, wherein the self-assembled structure contains 75% collagen type I in its native α

-helical structure, and

the resorbable orthopaedic implant has a plurality of indentations on a first surface thereof.

13. The orthopaedic device of claim 12, wherein the resorbable orthopaedic implant has a plurality of protrusions on a second surface thereof at locations corresponding with the locations of the plurality of indentations on the first surface.

14. The orthopaedic implant of claim 12, wherein the resorbable orthopaedic implant comprises a naturally occurring submucosal matrix.

15. The orthopaedic implant of claim 12, wherein the resorbable orthopaedic implant comprises:

at least one sheet of naturally occurring submucosal matrix secured to the self-assembled porous structure.

16. The orthopaedic implant of claim 12, wherein the resorbable orthopaedic implant comprises:

a number of sheets of naturally occurring submucosal matrix sandwiching the self-assembled porous structure.

17. The orthopaedic implant of claim 12, wherein:

the orthopaedic implant comprises an inner radial area and an outer radial area,

a first number of the indentations are positioned in the inner radial area,

a second, greater number of the indentions are positioned in the outer radial area.

18. The orthopaedic implant of claim 12, further comprising a bioactive agent.