Antibodies and related molecules that bind to PSCA proteins
First Claim
1. A monoclonal antibody or fragment thereof comprising an antigen binding site that binds specifically to a PSCA protein comprising the amino acid sequence of SEQ ID NO:
- 2, and wherein the monoclonal antibody comprises the amino acid sequence of the VH region and VL region of the antibody secreted by the hybridoma assigned A.T.C.C. Accession No.;
PTA-6701.
1 Assignment
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Accused Products
Abstract
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
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Citations
7 Claims
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1. A monoclonal antibody or fragment thereof comprising an antigen binding site that binds specifically to a PSCA protein comprising the amino acid sequence of SEQ ID NO:
- 2, and wherein the monoclonal antibody comprises the amino acid sequence of the VH region and VL region of the antibody secreted by the hybridoma assigned A.T.C.C. Accession No.;
PTA-6701. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 2, and wherein the monoclonal antibody comprises the amino acid sequence of the VH region and VL region of the antibody secreted by the hybridoma assigned A.T.C.C. Accession No.;
Specification