Method of producing a pigmented composite microporous material

• US 7,597,936 B2
• Filed: 05/26/2004
• Issued: 10/06/2009
• Est. Priority Date: 11/26/2002
• Status: Expired due to Fees

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Elgort, Mark G., Smith, Roger E., Voelkerding, Karl V., Durtschi, Jacob
• Primary Examiner(s): FLETCHER III, WILLIAM P
• Application Number:
  US10/853,808
• Publication Number:
  US 20040253624A1
• Time in Patent Office: 1,959 Days
• Field of Search: 4274191-4193, 427/419.8, 427243-245, 427/247
• US Class Current: 427/419.1
• CPC Class Codes: B01D 67/0065 by anodic oxidation
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: B01D 67/00931 by introduction of specific groups after membrane formation, e.g. by grafting
• CPC Class Codes: B01D 69/12 Composite membranes; Ultra-thin membranes
• CPC Class Codes: B01D 71/0221 Group 4 or 5 metals
• CPC Class Codes: B01D 71/02231 Palladium
• CPC Class Codes: B01D 71/02232 Nickel
• CPC Class Codes: B01D 71/025 Aluminium oxide
• CPC Class Codes: B01J 2219/00286 Reactor vessels with top and bottom openings
• CPC Class Codes: B01J 2219/00545 Colours
• CPC Class Codes: B01J 2219/00572 Chemical means
• CPC Class Codes: B01J 2219/00641 the porous medium being continuous, e.g. porous oxide substrates
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01J 2219/00725 Peptides
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2300/0829 Multi-well plates; Microtitration plates
• CPC Class Codes: B01L 2300/0851 Bottom walls
• CPC Class Codes: B01L 3/50255 Multi-well filtration
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 20/00 : Nanooptics, e.g. quantum optics or photonic crystals
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C12Q 1/68 : involving nucleic acids
• CPC Class Codes: C12Q 1/6813 : Hybridisation assays
• CPC Class Codes: C12Q 1/6844 : Nucleic acid amplification reactions
• CPC Class Codes: C12Q 1/703 : Viruses associated with AIDS
• CPC Class Codes: C12Q 2565/137 : Chromatographic separation
• CPC Class Codes: G01N 21/4738 : Diffuse reflection precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration, e.g. also for testing fluids, fibrous materials
• CPC Class Codes: G01N 21/6428 : Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/6456 : Spatial resolved fluorescence measurements; Imaging
• CPC Class Codes: G01N 21/6458 : Fluorescence microscopy fluorescence microscopes per se G02B21/0076 and G02B21/16
• CPC Class Codes: Y10T 428/249978 : Voids specified as micro

Abstract

Disclosed is a method for producing a pigmented composite comprising contacting a microporous material with a tin compound to form a composite then contacting the composite with a pigment comprising an elemental metal, a metal oxide, a metal alloy, a metal salt, or a combination thereof to produce the pigmented composite. The pigmented composites described herein are useful for separating one or more analytes present in a fluid sample.

Claims

1. A method for producing a pigmented composite, comprising:

a. contacting a microporous material with an aqueous solution of a tin compound to produce a first composite, wherein the microporous material comprises a ceramic, a metal, metal oxide, carbon, or glass; and

b. contacting the first composite with an aqueous solution of a first pigment comprising a palladium compound followed by contacting the first composite with an aqueous solution of a second pigment comprising a nickel compound to produce the pigmented composite.

2. The method of claim 1, wherein the metal oxide comprises aluminum oxide, zirconium oxide, titanium oxide, a zeolite, or a combination thereof.

3. The method of claim 1, wherein the microporous material comprises an inorganic electrochemically formed material or an etch material.

4. The method of claim 1, wherein the microporous material comprises aluminum oxide that is electrochemically formed or etched.

5. The method of claim 1, wherein the microporous material comprises micropores having a diameter of from about 0.02 microns to about 0.2 microns.

6. The method of claim 1, wherein the microporous material comprises aluminum or titanium that has been anodized.

7. The method of claim 1, wherein the tin compound comprises an organotin compound or a tin salt.

8. The method of claim 1, wherein the tin compound comprises a compound that produces Sn⁺² ions in solution.

9. The method of claim 1, wherein the tin compound comprises SnCl₂.

10. The method of claim 1, wherein the microporous material comprises aluminum oxide and the tin compound comprises a tin salt.

11. The method of claim 1, wherein after step (b), heating the pigmented composite.

12. The method of claim 1, further comprising after step (b), applying a suspension matrix to the pigmented composite, wherein the suspension matrix is localized near the surface of the pigmented composite.

13. The method of claim 12, wherein the suspension matrix comprises an oligonucleotide, a polysaccharide, a protein, an organic or inorganic polymer or macromolecule, or a combination thereof.

14. The method of claim 12, wherein when the suspension matrix comprises an oligonucleotide, wherein the oligonucleotide comprises a nucleic acid.

15. A method for producing a pigmented composite, comprising:

a. contacting a microporous material with an aqueous solution of a tin compound to produce a first composite, wherein the microporous material comprises aluminum oxide that is electrochemically formed or etched, or aluminum or titanium that has been anodized, and

b. contacting the first composite with an aqueous solution of a pigment comprising an elemental metal, a metal oxide, a metal alloy, a metal salt, or a combination thereof to produce the pigmented composite.

16. The method of claim 15, wherein the microporous material comprises micropores having a diameter of from about 0.02 microns to about 0.2 microns.

17. The method of claim 15, wherein the tin compound comprises an organotin compound or a tin salt.

18. The method of claim 15, wherein the tin compound comprises a compound that produces Sn⁺² ions in solution.

19. The method of claim 15, wherein the tin compound comprises SnCl₂.

20. The method of claim 15, wherein the pigment comprises a metal salt.

21. The method of claim 20, wherein when the metal salt comprises a transition metal salt.

22. The method of claim 21, wherein the transition metal salt comprises a palladium compound, a nickel compound, silver compound, gold compound, or a combination thereof.

23. The method of claim 15, wherein in step (b), the first composite is contacted with an aqueous solution of a first pigment followed by contacting the first composite with an aqueous solution of a second pigment.

24. The method of claim 23, wherein the aqueous solution of the first pigment comprises a palladium compound and the aqueous solution of the second pigment comprises a nickel compound.

25. The method of claim 15, wherein the microporous material comprises aluminum oxide and the tin compound comprises a tin salt, and wherein the first composite is contacted with an aqueous solution of a first pigment comprising a palladium compound and then an aqueous solution of a second pigment comprising a nickel compound.

26. The method of claim 15, wherein after step (b), heating the pigmented composite.

27. The method of claim 15, further comprising after step (b), applying a suspension matrix to the pigmented composite, wherein the suspension matrix is localized near the surface of the pigmented composite.

28. The method of claim 27, wherein the suspension matrix comprises an oligonucleotide, a polysaccharide, a protein, an organic or inorganic polymer or macromolecule, or a combination thereof.

29. The method of claim 27, wherein when the suspension matrix comprises an oligonucleotide, wherein the oligonucleotide comprises a nucleic acid.