Modulation of apolipoprotein C-III expression
First Claim
Patent Images
1. A method of treating an animal having hyperlipidemia, said method comprising:
- administering to an animal suffering from hyperlipidemia an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO;
4 and consists of 15 to 30 linked nucleosides, thereby reducing hyperlipidemia in said animal.
2 Assignments
0 Petitions
Accused Products
Abstract
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
-
Citations
28 Claims
-
1. A method of treating an animal having hyperlipidemia, said method comprising:
administering to an animal suffering from hyperlipidemia an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO;
4 and consists of 15 to 30 linked nucleosides, thereby reducing hyperlipidemia in said animal.- View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
2. A method of delaying the onset of hyperlipidemia in an animal, said method comprising:
administering to an animal at risk for developing hyperlipidemia an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO;
4 and consists of 15 to 30 linked nucleosides, thereby delaying the onset of hyperlipidemia.- View Dependent Claims (3)
-
4. A method of lowering cholesterol levels in an animal comprising:
administering to an animal in need of a reduction in cholesterol levels an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO;
4 and consists of 15 to 30 linked nucleosides, wherein said administering results in reduced cholesterol levels in said animal.- View Dependent Claims (5, 6, 7)
-
8. A method of lowering triglyceride levels in an animal comprising:
administering to an animal in need of a reduction in triglyceride levels an antisense compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO;
4 and consists of 15 to 30 linked nucleosides, wherein said administering results in reduced triglyceride levels in said animal.- View Dependent Claims (9, 10, 11)
Specification