Evaluating the urethra and the periurethral tissues

• US 7,599,729 B2
• Filed: 05/24/2005
• Issued: 10/06/2009
• Est. Priority Date: 04/25/1996
• Status: Expired due to Fees

• Current Assignee: SurgiVision Inc.
• Original Assignee: Johns Hopkins University, SurgiVision Inc.
• Inventors: Karmarkar, Parag, Quick, Harald Hartmut, Atalar, Ergin
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Brutus; Joel F
• Application Number:
  US11/136,329
• Publication Number:
  US 20060122493A1
• Time in Patent Office: 1,596 Days
• Field of Search: 600/407, 600/409, 600/410, 600/411, 600/423, 600/424, 324/318
• US Class Current: 600/423
• CPC Class Codes: A61B 1/273 for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
• CPC Class Codes: A61B 1/303 for the vagina, i.e. vaginoscopes
• CPC Class Codes: A61B 1/307 for the urinary organs, e.g. urethroscopes, cystoscopes
• CPC Class Codes: A61B 1/31 for the rectum, e.g. proctoscopes, sigmoidoscopes , colonoscopes
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/4381 Prostate evaluation or disorder diagnosis
• CPC Class Codes: G01R 33/285 Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
• CPC Class Codes: G01R 33/34007 Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system
• CPC Class Codes: G01R 33/34084 implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
• CPC Class Codes: G01R 33/341 comprising surface coils
• CPC Class Codes: H01Q 1/36 Structural form of radiating elements, e.g. cone, spiral, umbrella; Particular materials used therewithH01Q1/08, H01Q1/14 take precedence
• CPC Class Codes: H01Q 1/362 for broadside radiating helical antennas
• CPC Class Codes: H01Q 1/40 Radiating elements coated with or embedded in protective material
• CPC Class Codes: H01Q 1/44 using equipment having another main function to serve additionally as an antenna , e.g. means for giving an antenna an aesthetic aspectH01Q1/27 - H01Q1/34 take precedence
• CPC Class Codes: H01Q 11/08 Helical antennas

Abstract

Systems and methods for the evaluation of the urethra and periurethral tissues may involve an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in electrical communication with an interface circuit made up of a tuning-matching circuit, a decoupling circuit and a balun circuit. The interface circuit may also be in electrical communication with a MRI machine. In certain practices, the present invention provides methods for the diagnosis and treatment of conditions involving the urethra and periurethral tissues, including disorders of the female pelvic floor, conditions of the prostate and anomalies of the pediatric pelvis.

Claims

1. An apparatus for magnetic resonance imaging of an anatomic region of a human pelvis, comprising:

an endourethral magnetic resonance imaging (MRI) coil comprising an antenna;

an interface circuit interposed between the antenna and a MRI machine, said interface circuit being in electrical communication with the antenna and being in electrical communication with the MRI machine, said interface circuit comprising a tuning-matching circuit, a decoupling circuit and a balun circuit, wherein the balun circuit comprises a member exhibiting a high impedance at a MRI frequency of the MRI machine.

2. An apparatus according to claim 1, further comprising a non-conductive housing enveloping the antenna.

3. An apparatus according to claim 2, wherein the non-conductive housing is formed of a biocompatible flexible polymer material.

4. An apparatus according to claim 1, further comprising a second antenna in communication with the interface circuit, each of the antennas sized and configured for insertion into the anatomic region of the pelvis.

5. An apparatus according to claim 4, further comprises a decoupling paddle positioned between the antennas.

6. An apparatus according to claim 5, wherein the decoupling paddle is self-expandable.

7. An apparatus according to claim 4, wherein at least one of the antennas is a receive only antenna.

8. An apparatus according to claim 1, wherein the antenna is a loopless antenna.

9. An apparatus according to claim 1, wherein the antenna comprises at least one imaging loop coil.

10. An apparatus according to claim 4, wherein the first and the second antennas are each imaging loop coils.

11. An apparatus according to claim 4, wherein the first and the second antennas are one of an imaging loop coil and a loopless antenna.

12. An apparatus according to claim 10, wherein the first and the second antennas are substantially orthogonal.

13. An apparatus according to claim 9, wherein the at least one imaging loop coil is a self-expandable coil.

14. An apparatus according to claim 13, further comprises an introducer catheter, wherein the at least one self-expandable coil is accommodated within and is deployed at a proximal end of the catheter by retraction of the catheter.

15. An apparatus according to claim 14, further comprises a self-expandable decoupling paddle accommodated within the introducer catheter, and wherein said paddle is deployed by retracting the catheter.

16. An apparatus according to claim 15, wherein the self-expandable paddle is attached to an activation rod within the introducer catheter, and wherein the decoupling paddle is adjusted to provide coil isolation by means of the activation rod.

17. An apparatus according to claim 1, wherein the balun circuit comprises a core conductor surrounded by primary insulation, with primary shielding over the primary insulation, surrounded by secondary insulation, and with secondary shielding over the secondary insulation, with a distal end portion of the core conductor electrically connected to the imaging coil, and wherein the secondary shielding and the primary shielding are in electrical communication at a proximal end portion thereof.

18. An apparatus according to claim 17, wherein a coaxial cable defines at least one of the secondary insulation and/or the secondary shielding.

19. An apparatus according to claim 1, wherein the tuning-matching circuit comprises capacitors and a PIN diode, and wherein the secondary shielding extends over the capacitors and PIN diode.

20. An apparatus according to claim 1, wherein the imaging coil resides on a flex circuit.

21. An apparatus according to claim 18, further comprising a BNC connector having a ground in communication with the coaxial cable, with the primary and secondary shielding attached to the ground in the connector.

22. An apparatus according to claim 1, wherein a member of the balun circuit has an electrical length that is sufficient to form a quarter wavelength which transforms to high impedance at the operative frequency of the MRI machine to inhibit shield currents from setting up resonance on the coil thereby reducing heating effects.

23. An apparatus according to claim 17, wherein the core conductor, primary insulation, primary shielding, secondary insulation and secondary shielding are defined by a microcoaxial cable in a tubular braided sleeve.

24. An apparatus according to claim 1, further comprising an endourethral therapeutic system in communication with the interface circuit and comprising an endourethral therapeutic delivery device to deliver a mode of therapy transurethrally to an area of the anatomic region imaged by the endourethral imaging system, the mode of therapy comprising electromagnetic radiation including at least one of light energy, light energy produced by a laser, microwave energy, infrared radiation and ultraviolet radiation.

25. An apparatus according to claim 1, further comprising an ablation element in communication with the interface circuit.

31. A method of examining an anatomic region of a human pelvis, comprising:

providing an apparatus as defined by claim 1;

providing the MRI machine;

inserting the endourethral MRI coil into a human urethra;

situating the human pelvis within a main magnetic field of the MRI machine;

imposing the main magnetic field on the human pelvis;

applying RF pulses to the human pelvis to excite magnetic resonance signal within the human pelvis;

applying gradient magnetic pulses to said human pelvis to spatially encode the magnetic resonance signals;

receiving said magnetic resonance signals in said endourethral MRI coil;

emitting responsive output signals from said endourethral MRI coil; and

processing said output signals and converting them into information about the anatomic region of the human pelvis, thereby to examine the anatomic region.

32. A method of examining a prostate of a subject, comprising:

providing an apparatus as defined by claim 1;

providing the MRI machine;

inserting the endourethral MRI coil into a pro static urethra;

situating the prostate of the subject within a main magnetic field of the MRI machine;

using the MRI machine to excite magnetic resonance signals within tissues surrounding the prostatic urethra;

applying gradient magnetic pulses to the prostate to spatially encode the magnetic resonance signals;

receiving said magnetic resonance signals in said endourethral MRI coil and producing responsive output signals therefrom;

processing said output signals to obtain data about the tissues surrounding the prostatic urethra; and

evaluating said data to diagnose the abnormality of the prostate.

26. An apparatus for magnetic resonance imaging of an internal endourethral anatomic region of a patient, comprising:

an endourethral probe with an magnetic resonance imaging (MRI) coil comprising an antenna; and

an interface circuit interposed between the antenna and a MRI machine, said interface circuit being in electrical communication with the antenna and being in electrical communication with the MRI machine, said interface circuit comprising a tuning-matching circuit, a decoupling circuit and a balun circuit, wherein the balun circuit comprises a triaxial braiding layer, and wherein the balun circuit has a high impedance at an MRI operating frequency of the MRI machine.

27. An apparatus according to claim 26, further comprising a flexible non-conductive housing enclosing the antenna, and wherein a distal end portion of the probe comprises an ablation member.

28. An apparatus according to claim 26, further comprising a second antenna in communication with the interface circuit with a decoupling paddle between the antennas, and wherein at least one of the antennas is a receive only antenna.

29. An apparatus for magnetic resonance imaging of an internal endourethral anatomic region of a patient, comprising:

an endourethral probe with an magnetic resonance imaging (MRI) coil comprising an antenna; and

an interface circuit interposed between the antenna and a MRI machine, said interface circuit being in electrical communication with the antenna and being in electrical communication with the MRI machine, said interface circuit comprising a tuning-matching circuit, a decoupling circuit and a balun circuit, wherein the balun circuit comprises a coaxial cable configured to exhibit high impedance at an operating frequency of the MRI machine.

30. An apparatus according to claim 29, wherein the balun circuit is connected to the imaging coil and is in communication with a cable/coil junction that connects the balun circuit to an extension coaxial cable that engages an MRI scanner port, and wherein the balun circuit has a length sufficient so as to form a quarter wavelength which transforms to high impedance at the cable/coil junction at the MRI machine operating frequency to inhibit shield currents from setting up resonance, thus reducing heating effects.