Systems and methods for improving heart rate kinetics in heart failure patients

• US 7,599,741 B2
• Filed: 06/29/2006
• Issued: 10/06/2009
• Est. Priority Date: 06/29/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Dong, Yanting, Yu, Yinghong, Hopper, Donald L.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US11/478,015
• Publication Number:
  US 20080004664A1
• Time in Patent Office: 1,195 Days
• Field of Search: 607/2, 607/9, 607/11, 607 17- 26, 600/520
• US Class Current: 607/19
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration

Abstract

Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient'"'"'s heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient'"'"'s heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient'"'"'s intrinsic heart rate based on a profile of the patient'"'"'s heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.

Claims

1. A method for adaptively pacing a heart failure patient in response to patient activity using an implantable medical device, comprising:

determining onset of sustained patient activity;

determining that a heart rate parameter of the patient has reached a steady-state in response to the sustained patient activity;

determining a timing relationship between the onset of sustained patient activity and the heart rate parameter reaching the steady-state; and

one or both of initiating and changing a pacing therapy based on a comparison of the timing relationship to a profile of the patient'"'"'s heart rate response to varying workloads indicating slow heart rate response to the sustained patient activity.

2. The method of claim 1, wherein the steady-state of the heart rate parameter comprises a level intrinsic heart rate.

3. The method of claim 1, wherein determining onset of sustained patient activity comprises sensing that the patient has been active for a time duration exceeding a threshold ranging between about 30 seconds and about 6 minutes using an accelerometer, and wherein time of onset of sustained patient activity is determined to be the time at which the activity level of the patient is first elevated.

4. The method of claim 1, wherein determining onset of sustained patient activity comprises sensing that the patient'"'"'s stroke volume has reached a steady-state value in response to the patient activity.

5. The method of claim 1, wherein the pacing therapy is delivered at a rate sufficient to improve the patient'"'"'s heart rate response for reaching a steady-state heart rate appropriate for an exercise level of the sustained patient activity, the steady-state heart rate indicated as appropriate for the exercise level of the sustained activity by the profile of the patient'"'"'s heart rate response to varying workloads.

6. The method of claim 1, wherein the pacing therapy is delivered at a rate sufficient to improve chronotropic response of the patient to the sustained activity.

7. The method of claim 1, wherein the heart rate parameter comprises an intrinsic heart rate of the patient.

8. The method of claim 1, wherein the step of one or both of initiating and changing the pacing therapy comprises adjusting one or both of AV delay parameter and VV parameter of the pacing therapy.

9. The method of claim 1, wherein the patient profile comprises the patient'"'"'s intrinsic heart rate and a respiration parameter for each of multiple activity levels varying in workload, the multiple activity levels based on ranges of the respiration parameter.

10. The method of claim 9, wherein the patient profile further comprises an intrinsic heart rate-to-respiration parameter relationship based on measurements of the patient'"'"'s intrinsic heart rate and the respiration parameter for each of the multiple activity levels, the heart rate-to-respiration parameter relationship comprising one or both of a plot having a slope and a mathematical function.

11. The method of claim 1, comprising developing the patient'"'"'s profile using the implantable medical device during a learning procedure in which heart rate parameter data is taken for each of multiple activity levels varying in workload.

12. The method of claim 11, wherein the learning procedure comprises acquiring one or more of heart rate, minute ventilation, and mean heart rate response time for the patient at each of the multiple activity levels.

13. The method of claim 1, wherein:

the patient profile comprises a heart rate and a minute ventilation associated with each of a plurality of activity level ranges; and

slowness of the patient'"'"'s heart rate response is determined based on heart rate and minute ventilation values established for an activity level range of the profile corresponding to the patient'"'"'s actual activity level of the sustained patient activity.