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Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns

  • US 7,599,799 B2
  • Filed: 10/18/2002
  • Issued: 10/06/2009
  • Est. Priority Date: 10/27/1998
  • Status: Expired due to Fees
First Claim
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1. A method of determining a disease profile that best matches a patient profile, comprising:

  • (a) comparing, on a suitably programmed computer, a patient profile with reference profiles in a reference database to determine a measure of similarity between said patient profile and each said reference profiles, wherein said patient profile is obtained by projecting a first profile comprising measurements of a plurality of cellular constituents in a cell sample from said patient onto co-varying basis cellular constituent sets, and wherein said reference profiles are obtained by respectively projecting disease profiles each comprising measurements of said plurality of cellular constituents in a disease cell sample onto said co-varying basis cellular constituent sets, said co-varying basis cellular constituent sets being determined based upon co-variation of measurements of cellular constituents, under a plurality of different perturbations;

    (b) identifying, on a suitably programmed computer, a reference profile in said reference database that best matches said patient profile based on a maximum similarity among the measures of similarity determined in step (a); and

    (c) outputting to a user interface device, a computer readable storage medium, or a local or remote computer system;

    or displaying, said maximum similarity or the disease of said disease cell sample of the reference profile in said reference database that best matches said patient profile.

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