Method and device for the non-invasive assessment of bones

• US 7,601,120 B2
• Filed: 11/28/2002
• Issued: 10/13/2009
• Est. Priority Date: 11/30/2001
• Status: Active Grant

• Current Assignee: Oscare Medical Oy (Revenio Group Oyj)
• Original Assignee: Jussi Timonen, Patrick Nicholson, Petro Moilanen, Shu Lin Cheng
• Inventors: Nicholson, Patrick, Moilanen, Petro, Cheng, Shu Lin, Timonen, Jussi
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Fernandez; Katherine L
• Application Number:
  US10/496,559
• Publication Number:
  US 20050004457A1
• Time in Patent Office: 2,511 Days
• Field of Search: 600/442, 600/437, 600/438, 600/449, 735/99
• US Class Current: 600/438
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61B 8/4209 by using holders, e.g. positioning frames
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties

Abstract

A method for the in vivo non-invasive characterization of the material and architectural properties of a bone in which an ultrasonic wave is introduced into a bone in such way as to produce one or more guided wave modes within the bone, and the signals emerging from the bone are stored and analyzed to determine the propagation characteristics of the guided wave/s. These measured guided wave propagation characteristics are then processed to obtain estimates of desired bone properties such as cortical thickness, bone density and bone elastic constants. The invention also includes an unltrasound arrangement with movable transducers.

Claims

1. A method for non-invasive assessment of bones, the method comprising the steps of:

providing at least one transducer that functions as a transmitter and at least one transducer that functions as a receiver;

directing in vivo an ultrasound signal emitted by the transmitter onto a bone, the ultrasound signal propagating within the bone and being emitted from the bone,

detecting in vivo the ultrasound signal emitted from the bone with the receiver at two or more transmitter-to-receiver distances along the bone and recording the detected ultrasound signal,

calculating at least one bone property from the recorded signals using a method including

detecting one or more modes of Lamb waves, said one or more detected wave modes having a relationship with said bone property or properties,

measuring the velocity of said one or more detected wave modes, and

calculating the bone property or properties from the measured velocity or velocities.

2. Method according to claim 1, wherein the detected Lamb wave mode is the lowest asymmetric mode (the A0 mode).

3. Method according to claim 2, including

detecting two wave modes and measuring and recording velocities of the two wave modes, one mode being said A0 mode and the other mode being a first arriving wave,

producing an image of the amplitude of the received signal as a function of time and transmitter-to-receiver distance from the recorded signals,

identifying at least two propagating waves from the image, and

determining velocities of said propagating waves from the slopes of lines fitted to the propagating waves in the image.

4. Method according to claim 3, including

measuring the arriving signal at least at two different transmitter-to-receiver distances,

scanning the bone for a chosen length by sending signals in at one transmitting point and receiving response signals at a separate receiving point,

during the measurement, moving either the transmitting or receiving point, or both, continuously or in steps, and

recording the received response signals from a number of differing transmitter-to-receiver distances during the scan.

5. Method according to claim 3 wherein the contact pressure of the transducers are controlled by detecting the axial force and moving the transducers respectively.

6. Method according to claim 3 wherein the transmitting and/or the receiving transducer are placed at an angle to the bone surface and the ultrasonic beam travels to and from the bone through an intervening coupling medium.

7. Method according to claim 3 wherein the angle of the transducers to the bone can be changed during the measurement to identify particular angles favorable to the production and detection of specific types of waves.

8. Method according to claim 3 wherein the transmitting and/or receiving transducers are arrays of individual transducers that may be electronically controlled to achieve scanning without mechanical movement and/or to enhance the production and detection of specific waves, for example through electronically forming and steering the acoustic beam.

9. Method according to claim 3 wherein a Fourier transform is performed on the received signals to facilitate discrimination and measurement of one or more waves.

10. Method according to claim 3 wherein time-frequency analysis is performed on the received signals to facilitate discrimination and measurement of one or more waves.

11. Method according to claim 3 wherein a 2-dimensional Fourier transform is performed on the received signals as function of time and transmitter-to-receiver distance to facilitate discrimination and measurement of one or more waves.

12. Method according to claim 3 wherein filtering of the received signals is performed to facilitate discrimination and measurement of one or more waves.

13. Method according to claim 3 wherein a specified excitation signal is sent to the transmitting transducer in order to modify the frequency spectrum of the emitted signal and hence facilitate discrimination and measurement of one or more waves.

14. Method according to claim 3 wherein the phase velocity of a wave is determined by fitting a line to points of constant phase within a wave packet.

15. Method according to claim 3 wherein the group velocity of a wave is determined by fitting a line to the amplitude envelope of a wavepacket.

16. Method according to claim 1 wherein transmitting and/or receiving transducers are comb transducers composed of several transducer elements spaced a constant distance apart, so that they excite and detect guided waves with a constant wavelength determined by the spacing of the elements.

17. Method according to claim 1 wherein the attenuation of a wave is determined from a decrease in amplitude of that wave with increasing transmitter-to-receiver distance.

18. Method according to claim 1 wherein a low frequency of ultrasound is used such that the first arriving signal detected corresponds to the fundamental symmetric Lamb wave (S0 wave) in the bone.

19. Method according to claim 1 wherein a single transducer is aligned at right angles to the bone surface and is operated in pulse-echo mode, transmitting an ultrasonic signal to the bone and detecting the reflected signal from the bone and the time difference between the reflection from the upper and lower bone surfaces is determined, and is used to estimate bone thickness.

20. Method according to claim 1 wherein bone properties are estimated from Lamb wave measurements using a mathematical algorithm, comprising:

the calculation of Lamb wave parameters from a set of assumed bone properties using analytical Lamb wave theory,

comparison of the calculated Lamb wave parameters with the measured Lamb wave parameters, and derivation of an error parameter representing the difference between the two,

adjustment of the initial estimates of bone properties in such a way as to reduce the error parameter, and

repeated iteration of this process until the error parameter becomes acceptably small, the values of the bone properties then being taken as the best estimates of the true bone properties.

21. Method according to claim 1 wherein bone properties are estimated from Lamb wave measurements using an artificial neural network, comprising:

use of the measured Lamb wave parameters as input data for an artificial neural network whose outputs correspond to selected bone properties, and

training of said artificial neural network with experimental data from a range of bone phantoms and real bone samples of varying physical properties.

22. Method according to claim 1 wherein measurements are made at a number of locations within a bone so as to identify and characterize regions of abnormal bone properties.