Method and apparatus for assay of electrochemical properties

• US 7,601,249 B2
• Filed: 02/10/2003
• Issued: 10/13/2009
• Est. Priority Date: 02/10/2002
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Iyengar, Sridhar G., Harding, Ian S.
• Primary Examiner(s): Nguyen; Nam X
• Assistant Examiner(s): Dinh; Bach T
• Application Number:
  US10/504,199
• Publication Number:
  US 20050069892A1
• Time in Patent Office: 2,437 Days
• Field of Search: 204400-40315, 205/777.5, 205/778, 205/778.5
• US Class Current: 204/401
• CPC Class Codes: A61B 2562/04 Arrangements of multiple sensors of the same type
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: G01N 17/02 Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.

Claims

1. A method of estimating an analyte concentration in a sample in an electrochemical system said system comprising a measuring electrode, said method comprising:

applying a time-varying potential to the measuring electrode of the system to generate a signal;

measuring a signal at the measuring electrode;

computing at least one parameter of all or some portion of the signal; and

determining the analyte concentration by resolving an estimation equation based on Faradaic and nonfaradaic signal information, wherein the measuring electrode has a quantity of fouling on the surface thereof, wherein the fouling is determined by resolving the estimation equation based on the at least one parameter.

2. The method of claim 1, wherein the at least one parameter contains capacitive information about the electrochemical system.