Alginate gel scaffold having a plurality of continuous parallel microtubular copper capillaries
First Claim
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1. A biomaterial scaffold comprising an alginate gel and at least one stabilizing agent;
- wherein the alginate gel comprises a plurality of continuous parallel microtubular copper capillaries having a first end and a second end; and
wherein the at least one stabilizing agent cross-links the alginate gel; and
wherein the capillaries permit cell migration into the scaffold; and
wherein the at least one stabilizing agent comprises a carbodiimide.
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Abstract
The present invention provides copper capillary alginate gels stabilized with barium, chitosan, its derivates, or a combination thereof. These stabilized gels are useful as scaffolds for containing, growing, or regenerating biological agents and cells for in vivo or in vitro use.
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31 Claims
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1. A biomaterial scaffold comprising an alginate gel and at least one stabilizing agent;
- wherein the alginate gel comprises a plurality of continuous parallel microtubular copper capillaries having a first end and a second end; and
wherein the at least one stabilizing agent cross-links the alginate gel; and
wherein the capillaries permit cell migration into the scaffold; and
wherein the at least one stabilizing agent comprises a carbodiimide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- wherein the alginate gel comprises a plurality of continuous parallel microtubular copper capillaries having a first end and a second end; and
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14. A biomaterial scaffold comprising an alginate gel and at least one stabilizing agent;
- wherein the alginate gel comprises a plurality of continuous parallel microtubular copper capillaries having a first end and a second end; and
wherein the at least one stabilizing agent cross-links the alginate gel; and
wherein the capillaries permit cell migration into the scaffold; and
further comprising at least one biologically active agent, and wherein the at least one biologically active agent comprises a plurality of cells seeded within the continuous parallel microtubular copper capillaries. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- wherein the alginate gel comprises a plurality of continuous parallel microtubular copper capillaries having a first end and a second end; and
Specification