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Antibody peg positional isomers, compositions comprising same, and use thereof

  • US 7,601,817 B2
  • Filed: 05/28/2003
  • Issued: 10/13/2009
  • Est. Priority Date: 05/28/2002
  • Status: Active Grant
First Claim
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1. An isolated antibody molecule which is a modified Fab fragment, the amino acid sequences of whose light chain (SEQ ID NO:

  • 1) and heavy chain (SEQ ID NO;

    2) are as depicted in FIG. 2, wherein a polyethylene glycol (PEG) moiety is attached at Cys 214 of the light chain.

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