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Oral-intestinal vaccines against diseases caused by enteropathic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

  • US 7,604,811 B1
  • Filed: 12/10/1996
  • Issued: 10/20/2009
  • Est. Priority Date: 03/16/1984
  • Status: Expired due to Fees
First Claim
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1. A method for inducing an immune response in mammals comprising administering a pharmaceutical composition comprising an antigenic synthetic peptide containing CFA/I pilus protein T-cell epitopes encapsulated within a biodegradable polymeric matrix comprising poly (DL-lactide-co-glycolide) having a relative ratio between the amount of lactide and glycolide components within the range of 48:

  • 52 to 58;

    42, wherein the CFA-I pilus protein T-cell epitopes consist of the amino acid sequence;

    (SEQ ID NO;

         1) [4] (Asn-Ile-Thr-Val-Thr-Ala-Ser-Val-Asp-Pro),(SEQ ID NO;

         11) (Gly-Asn-Tyr-Ser-Gly-Val-Val-Ser-Leu-Val), and mixtures thereof.

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