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Excitable target marker detection

  • US 7,604,981 B1
  • Filed: 03/07/2003
  • Issued: 10/20/2009
  • Est. Priority Date: 03/08/2002
  • Status: Expired due to Fees
First Claim
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1. An array of micro-circuit arrangements for detecting excitable target markers located in an external medium, the array comprising:

  • a foundation layer having a first surface; and

    a plurality of micro-circuit arrangements coupled to the first surface in proximity to one another and arranged in an array, each micro-circuit arrangement including;

    an excitation source coupled to the first surface, and adapted to emit a first respective electromagnetic radiation in a direction predominately away from the foundation layer to excite a respective target marker into emitting a second respective electromagnetic radiation;

    at least one corresponding optical-detector coupled to the first surface in proximity to the excitation source and arranged in the array with the excitation source, the at least one corresponding optical-detector adapted to sense the second respective electromagnetic radiation from a second direction opposite the first direction and generate a respective detection signal responsive to sensing the respective second electromagnetic radiation; and

    a filter optically coupled to the at least one corresponding optical-detector, the filter being arranged and configured to attenuate the first respective electromagnetic radiation from being sensed by the at least one corresponding optical-detector;

    wherein first and second groups of the plurality of micro-circuit arrangements are configured differently based on at least one of;

    ability to sense fluorescence decay of the target marker at first and second times, respectively; and

    different filter responses provided respectively by the first and second groups of the plurality of micro-circuit arrangements.

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