Multi channel metering device

• US 7,608,221 B2
• Filed: 06/20/2006
• Issued: 10/27/2009
• Est. Priority Date: 06/29/2005
• Status: Active Grant

• Current Assignee: Eppendorf Se
• Original Assignee: Eppendorf AG
• Inventors: Wilmer, Jens, Link, Holger, Belgardt, Herbert
• Primary Examiner(s): Gordon; Brian R.
• Application Number:
  US11/471,252
• Publication Number:
  US 20070003445A1
• Time in Patent Office: 1,225 Days
• Field of Search: 422 63- 681, 422/100, 436/180, 738/633.2, 738/64
• US Class Current: 422/561
• CPC Class Codes: B01L 3/0217 of the plunger pump type medical syringes A61M
• CPC Class Codes: G01N 35/1067 for transfer to or from containers having different spacing

Abstract

Multi-channel metering device with displacement devices for displacing a plurality of air columns, a plurality of holders which comprise a shank for releasable connection to a pipette tip, a connector and a connecting channel extending from the free end of the shank to the connector, flexible pipes which connect the displacement devices to the connectors, a guide on which the holders may be displaced with shanks aligned parallel to one another and perpendicular to the guide, abutment surfaces on the faces of the holders facing one another, pins projecting from the holders, oriented perpendicular to the guide and the shanks, round chain links arranged on the pins of adjacent holders, a free space existing between the pins and the rounded portions of the round chain links when the abutment surfaces of the adjacent holders bear against one another, and a drive device which engages at least one of the two outer holders and by means of which the holders may be pushed apart and pushed together along the guide.

Claims

1. Multi-channel metering device comprising displacement devices (1, 2) for displacing a plurality of air columns, a plurality of holders (6) each which comprises a shank (7) for releasable connection to a pipette tip, a connector (9) and a connecting channel extending from a free end of the shank (7) to the connector (9), flexible pipes (19) which connect the displacement devices (1, 2) to the connectors (9), a guide (14) on which the holders (6) may be displaced with shanks (7) aligned parallel to one another and perpendicular to the guide (14), abutment surfaces (10, 11) on the faces of the holders (6) facing one another, two pins (12, 13) projecting from the holders (6), oriented perpendicular to the guide (14) and the shanks (7), round chain links (16) arranged on the pins (12, 13) of adjacent holders (6), a free space existing between the pins (12, 13) and the rounded portions of the round chain links (16), when the abutment surfaces (10, 11) of the adjacent holders (6) bear against one another, and a drive device (20) which engages at least one of two outer holders (6) and by means of which the holders (6) may be pushed apart and pushed together along the guide (14).

2. Multi-channel metering device according to claim 1, wherein the shanks (7) have a tapered end for mounting a pipette tip.

3. Multi-channel metering device according to claim 1, wherein the guide comprises a guide body (14) with a slot (15) which is penetrated by the holders (6).

4. Multi-channel metering device according to claim 1, wherein the holders (6) have a rectangular parallelepiped portion (8) which comprises the shank (7) on a lower face, the connector (9) on a upper face, the abutment surfaces (10, 11) on a left and right face and the pins (12, 13) on a front face and/or rear face.

5. Multi-channel metering device according to claim 1, wherein the shank (7) is passed through the slot (15) of the guide body (14) and the rectangular parallelepiped portion (8) is located with the lower face on the upper face of the guide body (14).

6. Multi-channel metering device according to claim 1, wherein the connectors are tube connections (9) onto which the flexible pipes (19) are clamped.

7. Multi-channel metering device according to claim 4, in which wherein the two pins (12, 13) project from the front faces or rear faces of the rectangular parallelepiped portion (8), the two pins (12, 13) on each rectangular parallelepiped portion (8) being offset in height, the pins (12, 13) connected via round chain links (16) having the same height, and adjacent round chain links (16) able to be partially pushed over one another when the holders (6) are pushed together.

8. Multi-channel metering device according to claim 1, wherein the drive device (20) comprises at least one toothed rack (21, 22) which engages one of the two outer holders (6) and of which the toothing meshes with the toothing of a gear (23).

9. Multi-channel metering device according to claim 8, wherein the drive device (20) comprises two toothed racks (21, 22), each of which engaging one of the two outer holders (6) and the toothings of which meshing with the toothing of the gear (23), on different faces of the gear (23).

10. Multi-channel metering device according to claim 8, wherein the gear (23) is coupled with a rotary knob (26) for manual operation.

11. Multi-channel metering device according to claim 10, wherein the rotary knob (26) is connected fixedly in rotation to the gear (23).

12. Multi-channel metering device according to claim 8, wherein the gear (23) is coupled with an electric drive motor.

13. Multi-channel metering device according to claim 12, wherein the gear (23) is coupled with the shaft of the drive motor via a pinion.

14. Multi-channel metering device according to claim 1, which comprises magnetic and/or latching devices for fixing the holders (6) in a final positions.

15. Multi-channel metering device according to claim 1, wherein the displacement devices (1, 2) have a plurality of parallel piston-cylinder devices with a cylinder and a longitudinally displaceable piston arranged therein, each cylinder being connected via a flexible pipe (19) to a connector (9).

16. Multi-channel metering device according to claim 15, wherein the pistons are connected to at least one further drive device.