Glycine betaine and its use
First Claim
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1. A controlled release pharmaceutical system suitable for delivering after administration in a time-controlled manner to the bloodstream of a mammal comprising an effective amount of an active compound selected from the group consisting of a compound of the formula (CH3)3N+(CH2)nCOO−
- , with n equal to 1, pharmaceutically acceptable salts thereof, and mixtures thereof.
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Abstract
The present invention provides pharmaceutical uses of betaines, and especially glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of blood disorders, such as blood coagulation and thrombi formation.
39 Citations
15 Claims
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1. A controlled release pharmaceutical system suitable for delivering after administration in a time-controlled manner to the bloodstream of a mammal comprising an effective amount of an active compound selected from the group consisting of a compound of the formula (CH3)3N+(CH2)nCOO−
- , with n equal to 1, pharmaceutically acceptable salts thereof, and mixtures thereof.
- View Dependent Claims (2, 3, 4)
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5. A controlled release pharmaceutical system for achieving a goal selected from the group consisting of treating a condition, reducing the incidence of a condition, and reducing the severity of a condition, whereby said condition is selected from the group consisting of blood flow disturbances, thrombosis, thromboembolic disorders, and combinations thereof, said system being adapted for releasing in a time controlled manner for at least 120 minutes, after administration, a therapeutically effective amount of an active compound selected from the group consisting of a compound of the formula (CH3)3N+(CH2)nCOO−
- , with n equal to 1, pharmaceutically acceptable salts of said compound, and mixtures thereof.
- View Dependent Claims (6, 7, 8, 9, 10)
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11. A controlled release pharmaceutical system tor releasing an effective therapeutic amount of a compound selected from the group consisting of a compound of the formula (CH3)3N+(CH2)nCOO−
- , with n equal to 1, pharmaceutically acceptable salts thereof, and mixtures thereof, wherein said system is adapted for controlling for at least 120 minutes the release of an effective amount of a compound of glycine betaine, pharmaceutically acceptable salts thereof, and mixtures thereof.
- View Dependent Claims (12, 13, 14)
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15. A controlled release pharmaceutical system for achieving a goal selected from the group consisting of treating a condition, reducing the incidence of a condition, and reducing the severity of a condition, whereby said condition is selected from the group consisting of blood flaw disturbances, thrombosis, thromboembolic disorders, and combinations thereof, said system being adapted for releasing in a time controlled manner for at least 2160 minutes, after administration, a therapeutically effective amount at an active compound selected from the group consisting of a compound of the formula (CH3)3N+(CH2)nCOO−
- , with n equal to 1, pharmaceutically acceptable salts thereof, and mixtures thereof.
Specification