Multi-functional plasmon-resonant contrast agents for optical coherence tomography

• US 7,610,074 B2
• Filed: 01/08/2004
• Issued: 10/27/2009
• Est. Priority Date: 01/08/2004
• Status: Active Grant

• Current Assignee: Board of Trustees of The University of Illinois, Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Original Assignee: Board of Trustees of The University of Illinois, Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Boppart, Stephen A., Wei, Alexander
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): Shahrestani; Nasir
• Application Number:
  US10/753,972
• Publication Number:
  US 20050171433A1
• Time in Patent Office: 2,119 Days
• Field of Search: 378/21, 378/62, 600/407, 600/420, 600/408, 600425-429
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 49/0065 the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
• CPC Class Codes: A61K 49/0093 Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A method of forming an image of a sample, comprising: forming an image of a mixture, by exposing the mixture to electromagnetic radiation; wherein the mixture comprises the sample and plasmon-resonant nanoparticles, and wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.

Claims

1. A method of forming an image by optical coherence tomography, comprising:

forming an image of a mixture by exposing the mixture to electromagnetic radiation;

wherein the mixture comprises a patient and plasmon-resonant nanoparticles, wherein the electromagnetic radiation is provided to the mixture using optical coherence tomography in the frequency range of infra-red to ultraviolet light, and wherein the plasmon-resonant nanoparticles are anisotropic metallic nanoparticles having an extinction coefficient of at least 10⁶M<sup>−

1</sup>cm<sup>−

1</sup> at a frequency in the range of 10¹² to 10¹⁷ Hz, wherein the anisotropic metallic nanoparticles comprise a magnetic metal, and wherein the magnetic metal is selected from nickel, cobalt, iron, and combinations thereof.

2. The method of claim 1, wherein the anisotropic metallic nanoparticles comprise nanorods or nanotriangles.

3. The method of claim 1, wherein the an isotropic metallic nanoparticles comprise gold.

4. The method of claim 1, wherein the anisotropic metallic nanoparticles further comprise a surface modification.

5. The method of claim 4, wherein the surface modification comprises a cross-linked surfactant shell.

6. The method of claim 5, wherein the cross-linked surfactant shell comprises at least one member selected from the group consisting of cross-linked resorcinarenes and cross-linked olefin.

7. The method of claim 6, further comprising, attached to the cross-linked surfactant shell, at least one member selected from the group consisting of folate, a monoclonal antibody, and a membrane receptor ligand.

8. The method of claim 1, further comprising exposing the mixture to magnetic field.

9. The method of claim 1, further comprising exposing the mixture to an electric field.

10. The method of claim 1, wherein the patient is a human patient.

11. A method of forming an image by optical coherence tomography, comprising:

administering to a patient, anisotropic metallic nanoparticles having an extinction coefficient of at least 10⁶M<sup>−

1</sup>cm<sup>−

1</sup> at a frequency in the range of 10¹² to 10¹⁷ Hz;

wherein the anisotropic metallic nanoparticles are gold nanorods with a magnetic tip, and wherein the magnetic tip is one metal selected from the group consisting of cobalt, nickel, and iron;

exposing the patient to electromagnetic radiation;

collecting reflected electromagnetic radiation; and

forming an enhanced contrast image from the collected electromagnetic radiation.

12. The method of claim 11, wherein the gold nanorods have an aspect ratio of 4:

1 to 10;

1 and a diameter of 10 nm to 100 nm.

13. The method of claim 11, wherein the patient is a human.