Method and apparatus for assessing left ventricular function and optimizing cardiac pacing intervals based on left ventricular wall motion
First Claim
1. A method for monitoring left ventricular function during delivery of a cardiac resynchronization therapy (CRT), comprising:
- deploying a motion sensor to a fixed location on a portion of a left ventricular lateral wall wherein the motion sensor generates a motion signal proportional to motion of the portion of the left ventricular lateral wall;
opening a data collection window during a portion of a selected cardiac cycle phase;
storing the motion signal throughout at least a part of the portion of the data collection window for a predetermined time interval or for more than one cardiac cycle;
verifying a heart rate stability characteristic during the predetermined time interval or for more than one cardiac cycleaveraging the stored motion signal;
determining a signal characteristic from the averaged stored signal that is representative of left ventricular function; and
delivering a cardiac resynchronization therapy (CRT) based at least in part upon the signal characteristic;
wherein the motion sensor consists of one from the group;
a piezoelectric sensor, an optical sensor, a Hall-effect type sensor, a capacitive sensor, a resistive sensor, an inductive sensor.
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Abstract
A system and method for monitoring left ventricular (LV) lateral wall motion and for optimizing cardiac pacing intervals based on left ventricular lateral wall motion is provided. The system includes an implantable or external cardiac stimulation device in association with a set of leads including a left ventricular epicardial or coronary sinus lead equipped with a motion sensor electromechanically coupled to the lateral wall of the left ventricle. The device receives and processes wall motion sensor signals to determine a signal characteristic indicative of systolic LV lateral wall motion or acceleration. An automatic pacing interval optimization method evaluates the LV lateral wall motion during varying pacing interval settings, including atrial-ventricular intervals and inter-ventricular intervals and selects the pacing interval setting(s) that correspond to LV lateral wall motion associated with improved cardiac synchrony and hemodynamic performance.
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Citations
21 Claims
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1. A method for monitoring left ventricular function during delivery of a cardiac resynchronization therapy (CRT), comprising:
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deploying a motion sensor to a fixed location on a portion of a left ventricular lateral wall wherein the motion sensor generates a motion signal proportional to motion of the portion of the left ventricular lateral wall; opening a data collection window during a portion of a selected cardiac cycle phase; storing the motion signal throughout at least a part of the portion of the data collection window for a predetermined time interval or for more than one cardiac cycle; verifying a heart rate stability characteristic during the predetermined time interval or for more than one cardiac cycle averaging the stored motion signal;
determining a signal characteristic from the averaged stored signal that is representative of left ventricular function; anddelivering a cardiac resynchronization therapy (CRT) based at least in part upon the signal characteristic; wherein the motion sensor consists of one from the group;
a piezoelectric sensor, an optical sensor, a Hall-effect type sensor, a capacitive sensor, a resistive sensor, an inductive sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for optimizing cardiac pacing intervals based on left ventricular function for delivery of a cardiac resynchronization therapy (CRT), comprising;
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placing a motion sensor into operative mechanical communication with a portion of a left ventricular lateral free wall so that the motion sensor generates a motion signal proportional to the motion of the left ventricular lateral free wall; enabling a temporal data collection window corresponding to a selected cardiac cycle phase; applying a cardiac pacing stimulus delivered according to a preselected set of test pacing parameters; sensing the motion signal during at least a part of the temporal data collection window or during a more than one cardiac cycle for at least some members of the preselected set of test pacing parameters; verifying a heart rate stability characteristic; averaging the motion signal for the at least some members of the preselected set of test pacing parameters; determining a signal characteristic from the averaged sensed signal that is representative of relatively improved left ventricular function during each of the selected test pacing parameters; storing a cardiac pacing timing parameter for a right ventricular pacing electrode and for a left ventricular pacing electrode that resulted in the relatively improved left ventricular function; delivering a cardiac resynchronization therapy (CRT) based upon the cardiac pacing timing parameter, wherein the motion sensor consists of one from the group;
a piezoelectric sensor, an optical sensor, a Hall-effect type sensor, a capacitive sensor, a resistive sensor, an inductive sensor.
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11. A method for monitoring left ventricular function during delivery of a cardiac resynchronization therapy (CRT), comprising:
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deploying a motion sensor to a portion of a left ventricular lateral wall of a patient'"'"'s heart, wherein the motion sensor generates motion signals proportional to motion of the portion of the left ventricular lateral wall and indicative of left ventricular function; storing the motion signals throughout at least portions of a plurality of cardiac cycles; verifying a heart rate stability characteristic during the plurality of cardiac cycles; determining a signal characteristic from the stored motion signals that is representative of left ventricular function; and dependant upon the verified heart rate stability characteristic, delivering a cardiac resynchronization therapy (CRT) based upon the signal characteristic to optimize left ventricular function. - View Dependent Claims (12, 13, 14, 15)
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16. A method for optimizing cardiac pacing intervals based on left ventricular function for delivery of a cardiac resynchronization therapy (CRT) of a patient'"'"'s heart, comprising;
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placing a motion sensor into operative mechanical communication with a portion of a left ventricular lateral free wall of the patient'"'"'s heart so that the motion sensor generates motion signals proportional to the motion of the left ventricular lateral free wall and indicative of left ventricular function; applying cardiac pacing stimuli delivered according to a preselected set of test pacing parameters; sensing the motion signal during at least a part of a plurality of cardiac cycles for at least some members of the preselected set of test pacing parameters; verifying a heart rate stability characteristic; determining a signal characteristic from the sensed signals that is representative of relatively improved left ventricular function during each of the selected test pacing parameters; storing a cardiac pacing parameter that resulted in the relatively improved left ventricular function; and dependant upon the verified heart rate stability characteristic, delivering a cardiac resynchronization therapy (CRT) based upon the stored cardiac pacing parameter. - View Dependent Claims (17, 18, 19, 20, 21)
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Specification