Multi-drug titration and evaluation
First Claim
1. A method for titrating a multi-modality therapy regimen in an individual patient, comprising performing multiple times the steps of:
- i) providing p modalities to said individual patient in a plurality of dose combinations;
ii) measuring one or more clinical endpoints in said individual patient;
iii) assigning, using a computer, measurements made in said measuring step for each of said one or more clinical endpoints to a desirability function;
iv) combining, using said computer, all desirability functions to obtain a composite desirability function for each of said plurality of dose combinations;
v) associating, using said computer, each composite desirability function with a vertex of a geometric figure, wherein said geometric figure has vertices, and wherein each of said vertices represents one of said plurality of dose combinations;
vi) outputting, using said computer, a next dose combination by applying an evolutionary operation direct search algorithm to said geometric figure;
wherein performing steps i)-vi) multiple times constitutes titration of said multi-modality therapy regimen in said individual patient; and
wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient.
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Accused Products
Abstract
Titration of a combination of drugs or treatment modalities within individual subjects is carried out using an evolutionary operation (EVOP) direct-search procedure such as the Nelder-Mead simplex. Desirability functions are incorporated to define the main response of interest and additional responses or constraints. Statistical methodology for determining whether the titrated treatment combination has resulted in an improvement in patient response and for evaluating whether a therapeutic synergism exists is also incorporated. Inferences can be made about the efficacy of the combination or about the individual drugs or treatment modalities that comprise the combination. This approach allows every patient the potential to benefit from the combination under study and permits the consideration of multiple endpoints simultaneously.
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Citations
22 Claims
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1. A method for titrating a multi-modality therapy regimen in an individual patient, comprising performing multiple times the steps of:
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i) providing p modalities to said individual patient in a plurality of dose combinations; ii) measuring one or more clinical endpoints in said individual patient; iii) assigning, using a computer, measurements made in said measuring step for each of said one or more clinical endpoints to a desirability function; iv) combining, using said computer, all desirability functions to obtain a composite desirability function for each of said plurality of dose combinations; v) associating, using said computer, each composite desirability function with a vertex of a geometric figure, wherein said geometric figure has vertices, and wherein each of said vertices represents one of said plurality of dose combinations; vi) outputting, using said computer, a next dose combination by applying an evolutionary operation direct search algorithm to said geometric figure;
wherein performing steps i)-vi) multiple times constitutes titration of said multi-modality therapy regimen in said individual patient; and
wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 11, 14, 16)
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10. A method for titrating a multi-modality therapy regimen in an individual patient, comprising performing multiple times the steps of:
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i) providing p modalities to said individual patient in a plurality of dose combinations; ii) measuring a clinical endpoint in said individual patient; iii) assigning, using said computer, said measurements obtained in said measuring step to a desirability function; iv) associating, using said computer, said measurements obtained in said measuring step for said clinical endpoint with a vertex of a geometric figure, wherein said geometric figure has vertices, and wherein each of said vertices represents one of said plurality of dose combinations; and v) outputting, using said computer, a next dose combination for said individual patient by applying an evolutionary operation direct search algorithm to said geometric figure, and vi) performing steps i)-v) multiple times, wherein performing steps i)-v) multiple times constitutes titration of said multi-modality therapy regimen in said individual patient; and
wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient. - View Dependent Claims (12, 13, 15, 17)
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18. A method for titrating a multi-modality therapy regimen in a plurality of patients, comprising the steps of:
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i) providing p modalities to an individual patient in a plurality of dose combinations; ii) measuring a clinical endpoint in said individual patient; iii) assigning, using a computer, measurements obtained in said measuring step to a desirability function; iv) associating, using said computer, said measurements made obtained in said measuring step for said clinical endpoint with a vertex of a geometric figure, wherein said geometric figure has vertices, wherein each of said vertices represents one of said plurality of dose combinations; and v) determining, using said computer, a next dose combination for said individual patient by applying an evolutionary operation direct search algorithm to said geometric figure, and vi) performing steps i)-v) multiple times, wherein said step of performing each of said steps constitutes titration of said multi-modality therapy regimen in said individual patient; and
wherein results of said method are shown, displayed or represented as a plot, table or geometric representation, which enables a physician or researcher to evaluate and adjust said multi-modality therapy regimen for said individual patient;vii) performing said steps i)-vi) of said method in each individual in said plurality of patients; viii) constructing, using said computer, a confidence ellipsoid about a central location of final dose combinations for said plurality of patients in p-dimensional dose space; and
ix) evaluating said confidence ellipsoid to determinewhether a combination of p modalitites is better than no treatment at all;
orwhether a combination of p modalities is better than a combination of fewer than p modalities. - View Dependent Claims (19, 20, 21, 22)
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Specification