MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery
First Claim
1. A ventilator system having a ventilation flow path for ventilating a subject, comprising:
- a mass flow controller;
a gas delivery valve disposed downstream of and in communication with the mass flow controller, the gas delivery valve being configured to selectively dispense a plurality of different gases to a subject;
a first gas source in fluid communication with the gas delivery valve;
a second gas source in fluid communication with the gas delivery valve;
a first pressure sensor located upstream of the gas delivery valve;
a second pressure sensor located downstream of the gas delivery valve; and
a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller configured to monitor the pressures measured by the first and second pressure sensors and the flow rate of the mass flow controller and automatically determine a delivered tidal volume using a reading of the flow rate of the mass flow controller when the first pressure is at a substantially steady state condition.
1 Assignment
0 Petitions
Accused Products
Abstract
Ventilator systems include: (a) a mass flow controller; (b) a gas delivery valve in communication with the mass flow controller and configured to selectively dispense a plurality of different gases to a subject; (c) a first gas source in fluid communication with the gas delivery valve; (d) a second gas source in fluid communication with the gas delivery valve; (e) a first pressure sensor located upstream of the gas delivery valve; (f) a second pressure sensor located downstream of the gas delivery valve; and (g) a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller comprising computer program code that monitors the pressures measured by the first and second pressure sensors and automatically dynamically adjusts the flow rate of the mass flow controller.
85 Citations
29 Claims
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1. A ventilator system having a ventilation flow path for ventilating a subject, comprising:
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a mass flow controller; a gas delivery valve disposed downstream of and in communication with the mass flow controller, the gas delivery valve being configured to selectively dispense a plurality of different gases to a subject; a first gas source in fluid communication with the gas delivery valve; a second gas source in fluid communication with the gas delivery valve; a first pressure sensor located upstream of the gas delivery valve; a second pressure sensor located downstream of the gas delivery valve; and a controller operatively associated with the first and second pressure sensors and the mass flow controller, the controller configured to monitor the pressures measured by the first and second pressure sensors and the flow rate of the mass flow controller and automatically determine a delivered tidal volume using a reading of the flow rate of the mass flow controller when the first pressure is at a substantially steady state condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A system for delivering hyperpolarized gas to a subject, comprising:
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a gas delivery valve configured to deliver hyperpolarized gas and at least one non-polarized gas to a subject; a mass flow controller disposed upstream of the gas delivery valve; a tracheal tube disposed downstream of the gas delivery valve; means for monitoring a first pressure in the ventilator system upstream of the gas delivery valve; means for monitoring a second pressure in the ventilator system downstream of the gas delivery valve; means for automatically obtaining readings of the mass flow controller; and means for automatically determining the tidal inspiration volume of hyperpolarized gas delivered to the subject in situ using the monitored first pressure and the value of a reading of the mass flow controller obtained when the first pressure is substantially constant. - View Dependent Claims (28, 29)
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Specification