Method for improving heat stability of composition containing water-soluble coenzyme-bound glucose dehydrogenase (GDH)
First Claim
1. A method for preparing a glucose sensor comprising (a) combining bovine serum albumin in a composition comprising soluble flavin-bound glucose dehydrogenase (GDH), thereby improving the heat stability of GDH over that achieved without the inclusion of the bovine serum albumin, and (b) heat drying the composition onto the surface of the glucose sensor.
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Abstract
The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH), comprising a step of combining, in a composition comprising soluble coenzyme-bound glucose dehydrogenase (GDH), the enzyme with any one or more selected from the group consisting of sugar alcohols, carboxyl group-containing compounds, alkali metal-containing compounds, alkali earth metal compounds, ammonium salts, sulfate salts and proteins, thereby improving the heat stability of GDH over that achieved without the inclusion of the compounds.
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Citations
6 Claims
- 1. A method for preparing a glucose sensor comprising (a) combining bovine serum albumin in a composition comprising soluble flavin-bound glucose dehydrogenase (GDH), thereby improving the heat stability of GDH over that achieved without the inclusion of the bovine serum albumin, and (b) heat drying the composition onto the surface of the glucose sensor.
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