Sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors
First Claim
1. A method of detecting a cancer in a mammal in vivo, the method comprising:
- a) administering to a mammal a radiolabeled compound or salt thereof of Formula
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Abstract
Novel benzamide compounds of Formula (I), Formula (II), and Formula (III), salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (II) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.
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Citations
39 Claims
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1. A method of detecting a cancer in a mammal in vivo, the method comprising:
a) administering to a mammal a radiolabeled compound or salt thereof of Formula - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of determining the proliferative status of cells comprised by a mammalian tumor in vivo, the method comprising:
a) administering to a mammal comprising a tumor, a radiolabeled compound or salt thereof of Formula - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A method of determining progression of a cancerous tumor in a mammal, the method comprising:
a) administering to a mammal a radiolabeled compound or salt thereof of Formula - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
Specification