Apparatus and methods for compensation of blood volume effects on NIR spectroscopic measurements of blood analytes
First Claim
1. A method for measuring a blood analyte concentration of a body part comprising:
- a) removing a portion or all of the blood from said body part by rolling an elastic band along said body part, or by applying a positive pressure to said body part using a pressure/vacuum system, to produce a modified body part;
b) recording first absorbance values of said modified body part;
c) filling said modified body part with blood to produce a filled body part;
d) recording second absorbance values of said filled body part;
e) obtaining a difference spectrum by subtracting said first absorbance values from said second absorbance values; and
f) applying a calibration algorithm for said blood analyte to the difference spectrum to measure the concentration of said blood analyte.
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Accused Products
Abstract
The present invention provides a method for measuring a blood analyte concentration of a body part comprising removing a portion or all of the blood from the body part to produce a modified body part, and recording a first absorbance value of the modified body part. This is followed by filling the body part with blood to produce a filled body part, and recording a second absorbance value of the filled body part. A difference spectrum is obtained by subtracting the first absorbance values from the second absorbance values, and a calibration algorithm for the blood analyte is applied to the difference spectrum, thereby measuring the concentration of the blood analyte. Also provided is an apparatus for determining the concentration of a blood analyte of a body part. The apparatus comprising a chamber of a size and shape to receive the body part, where the chamber comprises an element for withdrawing and reintroducing blood from the body part, when the body part is inserted within the chamber. The chamber also comprising one or more than one port for introducing electromagnetic radiation into the chamber and onto that body part, and collecting remaining electromagnetic radiation following interaction with the body part.
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Citations
26 Claims
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1. A method for measuring a blood analyte concentration of a body part comprising:
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a) removing a portion or all of the blood from said body part by rolling an elastic band along said body part, or by applying a positive pressure to said body part using a pressure/vacuum system, to produce a modified body part; b) recording first absorbance values of said modified body part; c) filling said modified body part with blood to produce a filled body part; d) recording second absorbance values of said filled body part; e) obtaining a difference spectrum by subtracting said first absorbance values from said second absorbance values; and f) applying a calibration algorithm for said blood analyte to the difference spectrum to measure the concentration of said blood analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus for measuring a blood analyte concentration of a body part, comprising:
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i) a chamber of a size and shape to receive said body part, said chamber comprising an elastic band for withdrawing and reintroducing blood from said body part when said body part is inserted within the chamber, ii) one, or more than one, port for introducing electromagnetic radiation into the chamber and onto said body part, and collecting remaining electromagnetic radiation following interaction with said body part, and iii) a processor configured to determine a blood analyte concentration from a difference spectrum obtained by subtracting measurements obtained after at least a portion of the blood from said body part has been withdrawn, from measurements obtained after the blood has been reintroduced into said body part. - View Dependent Claims (12, 13, 14)
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15. A method for measuring a blood analyte concentration of a body part comprising:
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a) removing a portion or all of the blood from said body part by rolling an elastic band along said body part, or by applying a positive pressure to said body part using a pressure/vacuum system, to produce a modified body part; b) recording first reflectance values of said modified body part; c) filling said modified body part with blood to produce a filled body part; d) recording second reflectance values of said filled body part; e) obtaining a difference spectrum by subtracting said first reflectance values from said second reflectance values, and f) applying a calibration algorithm for said blood analyte to the difference spectrum to measure the concentration of said blood analyte. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification