Spectroscopic cross-channel method and apparatus for improved optical measurements of tissue
First Claim
1. A sampling system for spectroscopic measurements of a biological sample, the sampling system comprising:
- a plurality of illumination points;
a plurality of detection points, wherein;
each of the plurality of illumination points is involved in at least two measurements of illumination through the biological sample, andeach of the plurality of detection points is involved in at least two measurements of illumination through the biological sample;
a memory for storing a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements; and
a processor configured to determine a value from the plurality of measurements that is related to the biological sample by compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points.
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Abstract
According to the invention, a sampling system for spectroscopic measurements of a biological sample is disclosed. The sampling system includes a plurality of illumination points, a plurality of detection points, a memory, and a processor. Each of the plurality of illumination points is involved in at least two measurements of illumination through the biological sample. Each of the plurality of detection points is involved in at least two measurements of illumination through the biological sample. The memory stores a plurality of measurements. The processor determines a value from the plurality of measurements that is related to the biological sample.
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Citations
40 Claims
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1. A sampling system for spectroscopic measurements of a biological sample, the sampling system comprising:
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a plurality of illumination points; a plurality of detection points, wherein; each of the plurality of illumination points is involved in at least two measurements of illumination through the biological sample, and each of the plurality of detection points is involved in at least two measurements of illumination through the biological sample; a memory for storing a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements; and a processor configured to determine a value from the plurality of measurements that is related to the biological sample by compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of performing spectroscopic determinations on a biological sample, the method comprising steps of:
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providing a plurality of illumination points; providing a plurality of detection points; measuring illumination incident on each of the plurality of detection points a plurality of times, wherein the measuring steps produce a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements; and determining a value for the biological sample from the plurality of measurements, comprising compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A sampler for spectroscopic measurements of a biological sample, the sampler comprising:
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a first illumination point that illuminates at least two detection points with measurable radiation; a second illumination point that illuminates said at least two detection points with measurable radiation; a first of said at least two detection points that receives measurable radiation from said first and second illumination points; a second of said at least two detection points that receives measurable radiation from said first and second illumination points, wherein the first illumination point, the second illumination point, the first detection point, the second detection point are configured to operatively engage the biological sample; and a controller in communication with the first and second illumination points and in communication with the first and second detection points to generate a plurality of measurements, each of the measurements including information defining a combination of a particular one of the plurality of illumination points and a particular one of the plurality of detection points involved in the each of the measurements, and to determine a value from the plurality of measurements that is related to the biological sample by compensating for interface noise terms from the combinations of particular ones of the plurality of illumination points and particular ones of the plurality of detection points. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40)
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Specification