Implantable vagal stimulator for treating cardiac ischemia

• US 7,613,511 B2
• Filed: 03/09/2005
• Issued: 11/03/2009
• Est. Priority Date: 03/09/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Wu, Eugene Yu-Chun, Libbus, Imad
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Patel; Natasha N
• Application Number:
  US11/075,838
• Publication Number:
  US 20060206158A1
• Time in Patent Office: 1,700 Days
• Field of Search: 607/2, 607/118, 607/9, 607/17, 607/44, 600/513
• US Class Current: 607/9
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A device and method for treating cardiac ischemia with vagal stimulation is disclosed. In one embodiment, an implantable device is configured to deliver vagal stimulation upon obtaining an indication of cardiac ischemia by analysis of a recorded electrogram.

Claims

1. A method for treating cardiac ischemia, comprising:

configuring an implantable device to monitor for an indication that an episode of cardiac ischemia is occurring, wherein such indication of cardiac ischemia includes changes in cardiac electrical activity;

configuring the implantable device with a magnetically or tactilely actuated switch;

configuring the implantable device to deliver electrical stimulation to the vagus nerve upon obtaining an indication of cardiac ischemia and upon actuation of the magnetically or tactilely actuated switch;

configuring the implantable device to inhibit delivery of electrical stimulation to the vagus nerve unless both an indication of cardiac ischemia is obtained and the magnetically or tactilely actuated switch is actuated;

configuring the implantable device to cease delivery of the electrical stimulation to the vagus nerve after a predetermined length of time; and

,

configuring the implantable device to cease delivery of the electrical stimulation to the vagus nerve upon actuation of the magnetically or tactilely actuated switch.

2. The method of claim 1 further comprising configuring the implantable device to deliver electrical stimulation to the vagus nerve in conjunction with the delivery of pacing pulses in a bradycardia pacing mode that enforces a minimum heart rate, wherein the pacing pulses are delivered as biventricular or left ventricle-only pacing.

3. The method of claim 1 further comprising obtaining an indication of cardiac ischemia by analyzing the morphology of a recorded electrogram.

4. The method of claim 3 further comprising configuring the implantable device to detect a dyspneic breathing pattern by measuring transthoracic impedance and wherein the indication of cardiac ischemia further includes detection of a dyspneic breathing pattern.

5. The method of claim 1 further comprising configuring the implantable device for:

delivering paces to a cardiac chamber in accordance with a programmed pacing mode;

sensing an evoked response to a pace and recording an electrogram therefrom; and

,

analyzing the recorded electrogram in order to detect a change indicative of cardiac ischemia.

6. The method of claim 5 wherein a change in the recorded electrogram indicative of cardiac ischemia are detected by looking for an increased current of injury in the recorded electrogram.

7. The method of claim 6 wherein an increased current of injury is looked for by cross-correlating the recorded electrogram with a reference electrogram.

8. The method of claim 1 further comprising configuring the implantable device to deliver vagal stimulation upon manual operation of the tactilely or magnetically actuated switch of the implantable device.

9. An implantable cardiac device, comprising:

one or more sensing channels for sensing cardiac activity;

a neural stimulation channel for delivering vagal stimulation;

a controller programmed to record an electrogram from the sensing channel and analyze the recorded electrogram;

wherein the controller is programmed to obtain an indication of cardiac ischemia if a change indicative of cardiac ischemia is detected in the recorded electrogram;

a magnetically or tactilely actuated switch;

wherein the controller is programmed to delivery vagal stimulation upon obtaining an indication of cardiac ischemia and actuation of the magnetically or tactilely actuated switch;

wherein the controller is programmed to inhibit delivery of electrical stimulation to the vagus nerve unless both an indication of cardiac ischemia is obtained and the magnetically or tactilely actuated switch is actuated;

wherein the controller is programmed to cease delivery of the vagal stimulation after a predetermined length of time; and

,

wherein the controller is programmed to cease delivery of the vagal stimulation upon actuation of the magnetically or tactilely actuated switch.

10. The device of claim 9 further comprising:

a pacing channel for pacing a cardiac chamber;

wherein the controller is programmed to deliver paces to the cardiac chamber in accordance with a programmed pacing mode; and

,

wherein the controller is programmed to record an electrogram from the sensed evoked response and analyze the recorded electrogram in order to detect a change indicative of cardiac ischemia.

11. The device of claim 9 wherein the controller is further programmed to log a detected change in the electrogram indicative of cardiac ischemia as a clinically significant event.

12. The device of claim 9 further comprising:

a transthoracic impedance sensor for detecting a patient'"'"'s breathing pattern; and

,

wherein the controller is programmed to obtain an indication of cardiac ischemia only if a change indicative of cardiac ischemia is detected in the recorded electrogram and a dyspneic breathing pattern is detected.

13. The device of claim 9 wherein the controller is further programmed to deliver vagal stimulation upon actuation of the magnetically or tactilely actuated switch.

14. The device of claim 9 further comprising pacing channels for delivering biventricular or left ventricle-only pacing and wherein the controller is further programmed to deliver vagal stimulation in conjunction with the delivery of pacing pulses in a bradycardia pacing mode that enforces a minimum heart rate, wherein the pacing pulses are delivered as biventricular or left ventricle-only pacing.

15. The device of claim 9 wherein the controller is programmed to detect a change in the recorded electrogram indicative of cardiac ischemia by looking for an increased current of injury in the recorded electrogram.

16. The device of claim 15 wherein the controller is programmed to look for an increased current of injury for by cross-correlating the recorded electrogram with a reference electrogram.