Analyte sensor
First Claim
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1. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
- a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample;
a reference solution having a known analyte concentration;
a flow control device configured to regulate exposure of the sensor to the biological sample and to the reference solution, wherein the flow control device is configured to intermittently expose the sensor to the biological sample and to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and
a computer system comprising programming configured to determine calibration information and to calibrate a signal associated with the biological sample therefrom, wherein the calibration information comprises steady state information and transient information, and wherein the transient information is obtained by processing a signal produced during exposure of the sensor to a step change in analyte concentration.
1 Assignment
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Accused Products
Abstract
Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.
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Citations
50 Claims
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1. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration; a flow control device configured to regulate exposure of the sensor to the biological sample and to the reference solution, wherein the flow control device is configured to intermittently expose the sensor to the biological sample and to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and to calibrate a signal associated with the biological sample therefrom, wherein the calibration information comprises steady state information and transient information, and wherein the transient information is obtained by processing a signal produced during exposure of the sensor to a step change in analyte concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration; a flow control device configured to regulate exposure of the sensor to the biological sample and to the reference solution, wherein the flow control device is configured to intermittently expose the sensor to the biological sample and to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and to calibrate a signal associated with the biological sample therefrom, wherein the calibration information is comprises steady state information determined from a signal associated with exposure of the sensor to the reference solution and transient information determined from a signal associated with exposure of the sensor to the biological sample. - View Dependent Claims (23, 24, 25, 26)
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27. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration; a flow control device configured to regulate exposure of the sensor to the biological sample and to the reference solution, wherein the flow control device is configured to intermittently expose the sensor to the biological sample and to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solVition during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with the biological sample therefrom, wherein the calibration information is determined at least in part from at least one of a signal associated with exposure of the sensor to the reference solution or a signal associated with exposure of the sensor to the biological sample, and wherein the computer system further comprises programming configured to diagnose a condition of the system responsive to at least one of transient information determined from the signal associated with exposure of the sensor to the reference solution or transient information determined from the signal associated with exposure of the sensor to the biological sample. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 49)
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41. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration, wherein the system is configured to expose the sensor to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with the biological sample therefrom, wherein the calibration information is determined from at least one of a signal associated with exposure of the sensor to the reference solution or a signal associated with exposure of the sensor to the biological sample, wherein the biological sample is at least one of unknown analyte concentration or uncalibrated analyte concentration, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, and wherein the offset is determined by processing an impulse response of the sensor'"'"'s signal during exposure of the sensor to a step change in analyte concentration. - View Dependent Claims (42, 43)
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44. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration, wherein the system is configured to expose the sensor to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with a biological sample therefrom, wherein the calibration information is determined from at least one of a signal associated with exposure of the sensor to the reference solution or a signal associated with exposure of the sensor to the biological sample, wherein the biological sample is of unknown analyte concentration or uncalibrated analyte concentration, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, and wherein the computer system further comprises programming configured to detect an interfering species responsive to a change in the offset above a predetermined amount.
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45. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration, wherein the system is configured to expose the sensor to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with the biological sample therefrom, wherein the calibration information is determined from at least one of a signal associated with exposure of the sensor to the reference solution or a signal associated with exposure of the sensor to the biological sample, wherein the biological sample is at least one of unknown analyte concentration or uncalibrated analyte concentration, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, and wherein the computer system further comprises programming configured to diagnose a condition of the host'"'"'s metabolic processes responsive to a change in the offset above a predetermined amount. - View Dependent Claims (46, 50)
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47. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration, wherein the system is configured to expose the sensor to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with the biological sample therefrom, wherein the calibration information is determined from at least one of a signal associated with exposure of the sensor to the reference solution or a signal associated with exposure of the sensor to the biological sample, wherein the biological sample is of unknown analyte concentration or uncalibrated analyte concentration, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, and wherein the computer system further comprises programming configured to diagnose an error and fail-safe responsive to a change in the offset above a predetermined amount.
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48. A system for monitoring analyte concentration in a biological sample of a host, the system comprising:
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a substantially continuous analyte sensor configured to produce a data signal indicative of an analyte concentration in a host during exposure of the sensor to a biological sample; a reference solution having a known analyte concentration, wherein the system is configured to expose the sensor to the reference solution, and wherein the system is configured to produce a data signal indicative of an analyte concentration in the reference solution during exposure of the sensor to the reference solution; and a computer system comprising programming configured to determine calibration information and calibrate a signal associated with the biological sample therefrom, wherein the calibration information is determined from at least one of a signal associated with exposure of the sensor to the reference solution and a signal associated with exposure of the sensor to the biological sample, wherein the biological sample is at least one of unknown analyte concentration or uncalibrated analyte concentration, wherein calibration information comprises baseline information, wherein the system comprises programming configured to determine an offset between a baseline associated with the reference solution and a baseline associated with the biological sample, and wherein the computer system further comprises programming configured to recalibrate the sensor responsive to a change in the offset above a predetermined amount.
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Specification