Apparatus and method for administering a therapeutic agent into tissue

• US 7,615,030 B2
• Filed: 06/15/2004
• Issued: 11/10/2009
• Est. Priority Date: 10/06/2003
• Status: Active Grant

• Current Assignee: ActiveO, Inc.
• Original Assignee: Active O, LLC
• Inventors: Muto, Mario, Murphy, Kieran
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US10/867,215
• Publication Number:
  US 20050074501A1
• Time in Patent Office: 1,974 Days
• Field of Search: 604/890.1, 604/891.1, 604143-147, 604/181, 604/184, 604/187, 604 23- 26, 128/202.25, 424/600, 422/186.07
• US Class Current: 604/25
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/40 Peroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 2005/3114 Filling or refilling
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 25/065 Guide needles
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids

Abstract

An apparatus for administering a therapeutic agent is provided. The apparatus, in an embodiment, includes an ozone generator connected to a scavenger and an ozone administrator via network of tubing and valves. When activated and the valves placed in the proper position, the ozone generator will fill the ozone administrator with ozone. The ozone generator can then be turned off and the valves moved so that the administrator can be disconnected from the remainder of the apparatus. The administrator is typically in the form of a syringe and needle. Once the syringe and needle is filled with ozone, the needle can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

Claims

1. A syringe for self-contained generation and administration of a therapeutic agent comprising:

a barrel for holding said agent;

a plunger for insertion into a first end of said barrel and expressing said agent from a second end of said barrel;

a power supply integrally mounted coaxially with said plunger;

a therapeutic agent generator integrally mounted coaxially with said plunger and in communication with said barrel through a channel in said plunger, said generator connected to said power supply and mounted coaxially with said plunger; and

a switch connected to said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent and fills said barrel therewith.

2. The syringe of claim 1 wherein said agent is ozone.

3. The apparatus of claim 2 wherein said ozone is gas and said generator is a medical ozone generator.

4. The apparatus of claim 2 wherein said ozone is a ratio of ozone (O₃) to oxygen (O₂).

5. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 1 μ

g/ml.

6. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 10 μ

g/ml.

7. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 20 μ

g/ml.

8. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 30 μ

g/ml.

9. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 40 μ

g/ml.

10. The apparatus of claim 4 wherein said ratio of ozone to oxygen is about 50 μ

g/ml.

11. The apparatus of claim 4 wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 1 μ

g/ml and about 90 μ

g/ml.

12. The apparatus of claim 4 wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 80 μ

g/ml.

13. The apparatus of claim 4 wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 20 μ

g/ml and about 70 μ

g/ml.

14. The apparatus of claim 4 wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 10 μ

g/ml and about 34 μ

g/ml.

15. The apparatus of claim 4 wherein said ratio of ozone in micrograms to oxygen in milliliters is between about 27 μ

g/ml to about 28 μ

g/ml.