Methods for treating irritable bowel syndrome
First Claim
1. A method of treating diarrhea-predominant irritable bowel syndrome in a mammalian subject comprising administering a peptide YY (PYY) to said mammalian subject, whereby intestinal transit of said subject is slowed by the action of said PYY.
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Accused Products
Abstract
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
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Citations
12 Claims
- 1. A method of treating diarrhea-predominant irritable bowel syndrome in a mammalian subject comprising administering a peptide YY (PYY) to said mammalian subject, whereby intestinal transit of said subject is slowed by the action of said PYY.
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6. A method for treating diarrhea-predominant irritable bowel syndrome in a human subject comprising parenterally administering to said subject a peptide YY (PYY) at a dose of from about 0.5 to about 500 picomoles/kg weight of the subject, whereby intestinal transit of said subject is slowed by the action of said PYY.
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7. A method of slowing the rate of upper gastrointestinal transit of a substance in a mammal comprising administering a peptide YY (PYY) to said mammal, whereby intestinal transit of said mammal is slowed by the action of said PYY.
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8. A method of delaying gastric emptying in a mammal comprising administering a peptide YY (PYY) to said mammal, whereby intestinal transit of said mammal is slowed by the action of said PYY.
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9. A method of treating diarrhea-predominant irritable bowel syndrome by manipulating the rate of upper gastrointestinal transit of a substance in a mammal having an intrinsic cholinergic afferent neural pathway projecting from a peptide YY-sensitive primary sensory neuron in the intestinal wall to a prevertebral celiac ganglion and having an adrenergic efferent neural pathway projecting from said ganglion to one or more enterochromaffin cells in the intestinal mucosa and/or to a serotonergic interneuron linked in a myenteric plexus and/or submucous plexus to an opioid interneuron, said opioid interneuron also being linked by an intestino-fugal opioid pathway projecting to said ganglion, with one or more neural connections to the central nervous system and back to the gut projecting from the ganglion, said method comprising:
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providing a pharmaceutically acceptable composition, comprising a peptide YY (PYY); and administering the pharmaceutically acceptable composition to the mammal, said PYY being delivered in an amount and under conditions such that the cholinergic intestino-fugal pathway, at least one prevertebral ganglionic pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron are activated by the action of said PYY, whereby the rate of gastrointestinal transit is slowed by the action of said PYY. - View Dependent Claims (10)
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11. A method of treating diarrhea-predominant irritable bowel syndrome in a human subject having a cholinergic afferent neural pathway projecting from a peptide YY-sensitive primary sensory neuron in the intestinal wall to a prevertebral celiac ganglion and having a adrenergic efferent neural pathway projecting from said ganglion to one or more enterochromaffin cells in the intestinal mucosa and/or to a serotonergic interneuron linked in a myenteric plexus to an opioid interneuron, said opioid interneuron also being linked by an intestino-fugal opioid pathway projecting to said ganglion, with one or more neural connections to the central nervous system and back to the gut projecting from the ganglion, said method comprising:
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providing a pharmaceutically acceptable composition, comprising a peptide YY (PYY); and administering the pharmaceutically acceptable composition to the human subject, said PYY being delivered in an amount and under conditions such that the cholinergic intestino-fugal pathway, one or more prevertebral ganglionic pathways, a gangalion to central nervous system pathway, the adrenergic efferent neural pathway, the serotonergic interneuron and/or the opioid interneuron is substantially reduced by the action of said PYY, whereby intestinal transit of said human subject is slowed by the action of said PYY. - View Dependent Claims (12)
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Specification