Electroprocessed collagen and tissue engineering
First Claim
1. Synthetic electrospun collagen fibers electrospun from a solvent comprising a halogenated alcohol comprising a repeated longitudinal banding pattern, wherein the repeated banding pattern occurs at a spacing of about 65 nm to about 67 nm;
- wherein the synthetic electrospun collagen fibers comprise a matrix and the matrix has an elastic modulus between about 0.5 and about 10 MPa when hydrated.
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Accused Products
Abstract
The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
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Citations
26 Claims
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1. Synthetic electrospun collagen fibers electrospun from a solvent comprising a halogenated alcohol comprising a repeated longitudinal banding pattern, wherein the repeated banding pattern occurs at a spacing of about 65 nm to about 67 nm;
wherein the synthetic electrospun collagen fibers comprise a matrix and the matrix has an elastic modulus between about 0.5 and about 10 MPa when hydrated. - View Dependent Claims (2, 26)
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3. A composition comprising electroprocessed collagen comprising a repeated longitudinal banding pattern, wherein the repeated banding pattern occurs at a spacing of about 65 nm to about 67 nm;
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wherein the electroprocessed collagen comprises synthetic electrospun collagen fibers electrospun from a solvent comprising a halogenated alcohol. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10)
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11. A composition comprising synthetic electroprocessed collagen in a matrix, the matrix comprising a pore size in a range of about 0.2 microns to about 2.3 microns;
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wherein the electroprocessed collagen comprises synthetic electrospun collagen fibers electrospun from a solvent comprising a halogenated alcohol and comprising a repeated longitudinal banding pattern; and
,wherein the repeated banding pattern occurs at a spacing of about 65 nm to about 67 nm. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. A composition comprising electroprocessed collagen comprising a blend of at least two types of collagen;
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wherein the electroprocessed collagen comprises synthetic electrospun collagen fibers electrospun from a solvent comprising a halogenated alcohol. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification