Piperazinyl derivatives as modulators of chemokine receptor activity

• US 7,615,556 B2
• Filed: 01/23/2007
• Issued: 11/10/2009
• Est. Priority Date: 01/27/2006
• Status: Active Grant

• Current Assignee: Bristol-Myers Squibb Company
• Original Assignee: Bristol-Myers Squibb Company
• Inventors: Carter, Percy H., Cavallaro, Cullen L., De Lucca, George V.
• Primary Examiner(s): Wilson; James O
• Assistant Examiner(s): Leeser; Erich A
• Application Number:
  US11/625,889
• Publication Number:
  US 20070179148A1
• Time in Patent Office: 1,022 Days
• Field of Search: 514/253.13, 514/255.01, 544/365, 544/360, 544/384, 544/391, 544/386
• US Class Current: 514/253.13
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 213/56 Amides
• CPC Class Codes: C07D 295/185 from aliphatic carboxylic acids

Abstract

The present application describes modulators of MIP-1α of formula (I):

or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, T, W, R₁, R₄, R₅, R_5a and R_5b are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.

Claims

1. A compound of Formula (I):

2. The compound of claim 1, wherein the compound is a compound of formula (Ia) or (Ib):

3. The compound of claim 1, wherein the compound is a compound of formula (Ic)

4. The compound of claim 3, wherein:

T is

5. The compound of claim 1, wherein the compound is a compound of formula (Id):

6. The compound of claim 5, wherein:

T is

7. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 1.

8. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 3.

9. A pharmaceutical compostion comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 5.