Inhibitors of ion channels

• US 7,615,569 B2
• Filed: 08/11/2006
• Issued: 11/10/2009
• Est. Priority Date: 08/16/2005
• Status: Expired due to Fees

• Current Assignee: Icagen, Inc.
• Original Assignee: Icagen, Inc.
• Inventors: Wang, Xiaodong, Suto, Mark J., Marron, Brian, Fulp, Alan
• Primary Examiner(s): Anderson; Rebecca L
• Assistant Examiner(s): NOLAN, JASON MICHAEL
• Application Number:
  US11/464,057
• Publication Number:
  US 20070078145A1
• Time in Patent Office: 1,187 Days
• Field of Search: 548/193, 544/310, 514/274, 514/370, 514/365
• US Class Current: 514/370
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/06 Antiarrhythmics
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 417/14 containing three or more hetero rings

Abstract

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

Claims

1. A compound according to Formula I:

2. The compound of claim 1, wherein m and n are 0.

3. The compound of claim 1, wherein A is a member selected from:

4. The compound of claim 3, wherein J-R¹⁶ has the formula:

5. The compound of claim 3, having the formula:

6. The compound of claim 1, having inhibitory activity against a voltage-gated sodium channel.

7. A pharmaceutical formulation comprising the compound of claim 1.

8. A method of modulating activity of a sodium channel in a subject, said method comprising:

administering to said subject an amount of the compound of claim 1 sufficient to modulate said activity.

9. A method of ameliorating or alleviating a condition in a subject, wherein said condition is a member selected from pain, irritable bowel syndrome, Crohn'"'"'s disease, epilepsy, seizures, multiple sclerosis, bipolar depression and tachy-arrhythmias, said method comprising:

administering to said subject an amount of the compound of claim 1 sufficient to ameliorate or alleviate said condition.

10. The method according to claim 9, wherein said condition is pain, and said pain is a member selected from acute pain, chronic pain, visceral pain, inflammatory pain and neuropathic pain.

11. The compound of claim 1, wherein the compound has the formula:

12. The compound of claim 1, wherein A is

13. The compound of claim 1, wherein A is