Manufacturing methods for an apparatus for the controllable modification of compound concentration in a tube

• US 7,616,989 B2
• Filed: 10/26/2001
• Issued: 11/10/2009
• Est. Priority Date: 10/22/1999
• Status: Active Grant

• Current Assignee: Biosynergetics, Inc.
• Original Assignee: Biosynergetics, Inc.
• Inventors: Nyhart, Eldon H. Jr.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): KOHARSKI, CHRISTOPHER
• Application Number:
  US10/045,550
• Publication Number:
  US 20020115958A1
• Time in Patent Office: 2,937 Days
• Field of Search: 604 20- 22, 604 65- 67, 6048901-8921, 607/2
• US Class Current: 604/20
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 39/08 Tubes; Storage means specially adapted therefor
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances

Abstract

Apparatus and methods for delivery of a drug or compound into a fluid flowing within a tube or catheter. In one embodiment a catheter includes an inner surface coated with a polymer matrix such as a hydrogel. The hydrogel includes captured within it a therapeutic agent. The method of capture may be by various means, including photolabile bonds between the therapeutic agent and the hydrogel. The therapeutic agent is released from the hydrogel by the application of energy to the hydrogel, such as by a laser emitting a wavelength which resonates and breaks the photolabile bond. The released therapeutic agent diffuses out of the hydrogel into the liquid flowing within a lumen of the catheter.

Claims

1. A method for providing a compound to a system comprising:

providing a compound releasably captured within a matrix material, the compound being releasable upon receiving an energy input, a source of energy, and a controller operatively connected to the source and using a control signal to operate the source;

preparing a control signal using fractal mathematics;

placing the matrix material and captured compound in fluid communication with the system; and

operating the controller with the control signal and providing energy to the matrix material sufficient to release a portion of the compound into the system.

2. The method of claim 1 wherein the compound elicits a response of the system and the control signal is based on the response.

3. The method of claim 1 wherein the system is the circulatory system of a biological unit and the response is a response of the heart.

4. The method of claim 1 wherein the system is the neurological system of a biological unit and the therapeutic agent is an anesthetic.

5. The method of claim 1 wherein the system is the neurological system of a biological unit and the therapeutic agent is a neurotransmitter.

6. The method of claim 1 wherein the matrix material is attached to a catheter and the catheter is inserted into the system.

7. The method of claim 1 wherein the control signal has a frequency content generally less than about 1 Hertz.

8. The method of claim 1 wherein said operating includes releasing predetermined amounts of compound at predetermined intervals.

9. The method of claim 1 wherein said operating includes releasing variable amounts of compound at predetermined intervals.

10. The method of claim 1 wherein said operating includes releasing variable amounts of compound at variable intervals.

11. The method of claim 1 wherein said providing includes a sensor operatively connected to said controller, and a catheter, the matrix being attached to the catheter, and which further comprises sensing a second response of the system, wherein said operating is in response to said sensing.

12. The method of claim 1 wherein the control signal is based on a fractal representation of the system.