Devices and methods for cardiovascular reflex control via coupled electrodes

• US 7,616,997 B2
• Filed: 03/27/2003
• Issued: 11/10/2009
• Est. Priority Date: 09/27/2000
• Status: Expired due to Term

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Keith, Peter T., Serdar, David J., Persson, Bruce J., Rossing, Martin A., Kieval, Robert S.
• Primary Examiner(s): Bockelman; Mark W
• Assistant Examiner(s): Bertram; Eric D
• Application Number:
  US10/402,393
• Publication Number:
  US 20040019364A1
• Time in Patent Office: 2,420 Days
• Field of Search: 600/377, 600/381, 600/505, 607/44, 607/60, 607/62, 607/116, 607/118
• US Class Current: 607/44
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna

Abstract

Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.

Claims

1. A method for activating a baroreflex, said method comprising:

transmitting a control signal from a transmitting coil implanted in a vein proximate the baroreceptor;

wherein the control signal is wirelessly received by an activation device comprising both (a) an electrode structure and (b) a receiving coil, separately formed from the electrode structure wherein the activation device is implanted in or on a blood vessel proximate to the baroreceptor, whereby the control signal induces electrical current in the receiving coil, which current flows to the electrode structure which activates the baroreceptor to produce a baroreflex.

2. A method as in claim 1, wherein the control signal is transmitted from a location in the vein adjacent to the baroreceptor.

3. A method as in claim 2, wherein the control signal is generated by a control system implanted remotely from an arterial baroreceptor, wherein the control system is wired through a venous lumen to a transmitter in the vein adjacent to the arterial baroreceptor.